Lung Perfusion in Hemorrhagic Shock of Rats: The Effects of Resuscitation with Whole Blood, Saline or Hes 6%
| Autor: | Sedat Kaya, Selim Turhanoglu, Ayse Dicle Turhanoglu, Alper Kararmaz |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Pulmonary Circulation Resuscitation medicine.medical_treatment Hypovolemia Plasma Substitutes Blood Pressure Blood volume Shock Hemorrhagic Sodium Chloride Hydroxyethyl starch General Biochemistry Genetics and Molecular Biology Hydroxyethyl Starch Derivatives Rats Sprague-Dawley Blood Transfusion Autologous Random Allocation Albumins medicine Animals Humans Saline Whole blood Heparin business.industry Technetium General Medicine Rats Perfusion Blood pressure Anesthesia medicine.symptom business medicine.drug |
| Zdroj: | The Tohoku Journal of Experimental Medicine. 195:245-251 |
| ISSN: | 1349-3329 0040-8727 |
| DOI: | 10.1620/tjem.195.245 |
| Popis: | This study was undertaken to determine the effects of various resuscitation regimens on lung perfusion following resuscitation from hemorrhagic shock. Fourty male Sprague-Dawley rats (250-300 g) were used. The rats were divided randomly into four groups (n = 10 for each) and were sedated with intramuscular ketamine (100 mg/kg). We measured blood pressure, rectal temperature and lung perfusion using radioscintigraphy with a technetium colloid indicator. The systolic blood pressure was decreased 75% by removing blood via v. jugularis in the first three groups and group 4 was accepted as the control group, and blood volume was not diminished. Then the first three groups were resuscitated with autologous blood containing 125 units heparine/ml in group 1, saline in group 2, and hydroxyethyl starch (HES) 6% in group 3. After the correction of hypovolemia, all animals were injected 100 Bg (0.1 cc) technetium 99 m macroaggregated albumin (99mTc MAA) via penil vein. After injection of 99mTc MAA, 3 minutes fixed images were detected by a y camera in posterior position at 15 minutes and 5 hours. 99mTc MAA "wash out" rate in lung was determined quantitatively at 5 hours. Compared to a control group, lung perfusion was decreased significantly in groups resuscitated with saline, and HES 6% while perfusion was restored with autologous blood. We conclude that heparinized autologous blood saved lung capillary circulation in hemorrhagic shock in rats. |
| Databáze: | OpenAIRE |
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