Consequences of systemic venous drainage and denervation of heterotopic pancreatic transplants for insulin/C-peptide profiles in the basal state and after oral glucose
| Autor: | Michael A. Nauck, U. T. Hopt, T. Baartz, Werner Creutzfeldt, J. Talartschik, H. D. Becker, A. Baartz, E. G. Siegel, M. Büsing |
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| Rok vydání: | 1991 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Transplantation Heterotopic Endocrinology Diabetes and Metabolism medicine.medical_treatment Renal function 030209 endocrinology & metabolism Endogeny 030204 cardiovascular system & hematology Biology Pancreas transplantation Veins 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Reference Values Internal medicine Internal Medicine medicine Humans Insulin Denervation C-Peptide C-peptide Glucose Tolerance Test Kidney Transplantation Peripheral Diabetes Mellitus Type 1 Endocrinology chemistry Basal (medicine) Pancreas Transplantation Follow-Up Studies |
| Zdroj: | Diabetologia. 34:S81-S85 |
| ISSN: | 1432-0428 0012-186X |
| Popis: | Plasma glucose, immunoreactive insulin and C-peptide concentrations were compared in nine pancreas-kidney-transplanted patients (systemic venous drainage) and in ten non-diabetic kidney-transplanted patients with similar kidney function. In the basal state, C-peptide (insulin secretion) was similar, but immunoreactive insulin was higher and glucose concentrations were slightly, but significantly lower in pancrease-transplanted patients. After 50 g oral glucose, the plasma glucose and IR-insulin profiles were similar in both groups. The circumvention of first-pass hepatic insulin extraction (decreased endogenous insulin clearance) was compensated for by a significant reduction in insulin secretion (C-peptide; p = 0.036). In conclusion, hyperinsulinaemia in pancreas-transplanted patients with systemic venous drainage is significant only in the basal state. Insulin delivered into the portal and peripheral circulation, when leading to similar insulin profiles, maintains comparable degrees of glucose tolerance. |
| Databáze: | OpenAIRE |
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