Effects of Trypanosoma brucei brucei infection and diminazene aceturate administration on the blood pressure, heart rate, and temperature of Wistar albino rats
| Autor: | Emmanuella Olubanke Amope Sogebi, O E Adeleye, Jude Makinde Ale, J. O. Olukunle, Ladoke A. Durotoye, Samuel Olufemi Adeyemi, A. I. Adeleye |
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| Rok vydání: | 2017 |
| Předmět: |
0106 biological sciences
Male Physiology Trypanosoma brucei brucei Blood Pressure 030204 cardiovascular system & hematology Pharmacology Trypanosoma brucei 010603 evolutionary biology 01 natural sciences Body Temperature 03 medical and health sciences Diminazene 0302 clinical medicine Heart Rate Drug Discovery Heart rate medicine Diminazene aceturate Animals Statistical analysis Rats Wistar Treated group biology business.industry General Medicine biology.organism_classification Trypanocidal Agents Rats Blood pressure Trypanosomiasis African End of day business medicine.drug |
| Zdroj: | Journal of basic and clinical physiology and pharmacology. 29(3) |
| ISSN: | 2191-0286 |
| Popis: | Background:This study was carried out to determine the blood pressure changes in experimentallyTrypanosoma brucei brucei-infected Wistar albino rats and diminazene aceturate-treated rats.Methods:Twenty-four rats were purchased and divided into four groups consisting of six rats each. Control group (CON) received 0.5 mL of distilled water, i.m., infected but not treated group (INF) received 2×106trypanosome/mL i.m., infected but diminazene aceturate-treated group (INFDIM) received 2×106trypanosome/mL, 3.5 mg/kg, i.m.) and non-infected but diminazene aceturate-treated group (DIM) received 3.5 mg/kg, i.m. and served as negative control. The blood pressures were measured using a CODA 2®non-invasive blood pressure monitor (Kent Scientific, USA). The results were compiled and statistical analysis was done with significance set at p≥0.05.Results:The values of the blood pressure readings of theTrypanosoma-infected INF (137.0±2.0 mmHg) and diminazene-treated rats INFDIM (125.0±7.5 mmHg) when compared to the control group (168.0±3.0 mmHg) were significantly lower (p≤0.05) at the end of day 7. The heart rate was also significantly reduced in the INF (403.5±1.5 beats/min) and DIM (445.0±24 beats/min) groups of rats when compared with the control group (613.0±2.0 beats/min) at the end of day 8.Conclusion:The findings indicate the significant reduction in blood pressure and heart rates duringTrypanosoma brucei bruceiinfection and with diminazene aceturate administration. Hence, caution should be exercised when treating trypanosome-infected patients with diminazene aceturate. |
| Databáze: | OpenAIRE |
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