Ocular measurements in fetal alcohol spectrum disorders
| Autor: | Diego A. Gomez, Margaret P. Adam, Elizabeth Lyden, Kenneth L. Jones, Philip A. May, Julie M. Hasken, Luther K. Robinson, H. Eugene Hoyme, Melanie A. Manning, David Buckley, Wendy O. Kalberg, Barbara G. Tabachnick, Omar A. Abdul-Rahman |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Pediatrics medicine.medical_specialty Microcephaly Alcohol Drinking Fetal alcohol syndrome 030105 genetics & heredity Eye 03 medical and health sciences Fetal alcohol Pregnancy Genetics medicine Animals Humans Epidemiologic research Child Maternal-Fetal Exchange reproductive and urinary physiology Genetics (clinical) Growth deficiency business.industry medicine.disease female genital diseases and pregnancy complications 030104 developmental biology Palpebral fissure Fetal Alcohol Spectrum Disorders Neural Crest Face Female Interpupillary distance Underweight medicine.symptom business |
| Zdroj: | American Journal of Medical Genetics Part A. 182:2243-2252 |
| ISSN: | 1552-4833 1552-4825 |
| DOI: | 10.1002/ajmg.a.61759 |
| Popis: | Fetal alcohol spectrum disorders (FASD) describe a range of physical, behavioral, and neurologic deficits in individuals exposed to alcohol prenatally. Reduced palpebral fissure length is one of the cardinal facial features of FASD. However, other ocular measurements have not been studied extensively in FASD. Using the Fetal Alcohol Syndrome Epidemiologic Research (FASER) database, we investigated how inner canthal distance (ICD), interpupillary distance (IPD), and outer canthal distance (OCD) centiles differed between FASD and non-FASD individuals. We compared ocular measurement centiles in children with FASD to non-FASD individuals and observed reductions in all three centiles for ICD, IPD, and OCD. However, when our non-FASD children who had various forms of growth deficiency (microcephaly, short-stature, or underweight) were compared to controls, we did not observe a similar reduction in ocular measurements. This suggests that reductions in ocular measurements are a direct effect of alcohol on ocular development independent of its effect on growth parameters, which is consistent with animal models showing a negative effect of alcohol on developing neural crest cells. Interpupillary distance centile appeared to be the most significantly reduced ocular measure we evaluated, suggesting it may be a useful measure to be considered in the diagnosis of FASD. |
| Databáze: | OpenAIRE |
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