Interferon-β increases the stimulatory capacity of monocyte-derived dendritic cells to induce IL-13, IL-5 and IL-10 in autologous T-cells
| Autor: | Daniela Sönmez, Elke Wiesemann, Fedor Heidenreich, Anja Windhagen |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
T-Lymphocytes
medicine.medical_treatment Immunology Integrin alphaXbeta2 chemical and pharmacologic phenomena medicine.disease_cause Monocytes Autoimmunity Antigens CD1 Immune system medicine Humans Immunology and Allergy Secretion Interleukin 5 Receptors Interferon Interleukin-13 Follicular dendritic cells Chemistry hemic and immune systems Dendritic Cells Interferon-beta Interleukin-10 Interleukin 10 Cytokine Neurology Interleukin 13 Neurology (clinical) Interleukin-5 |
| Zdroj: | Journal of Neuroimmunology. 123:160-169 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/s0165-5728(01)00482-9 |
| Popis: | Dendritic cells (DCs) are key regulators of immune responses and have been associated with autoimmunity in animal models and human disease. The effects of interferon beta (IFN-beta), an immunomodulatory cytokine used in multiple sclerosis (MS) therapy, on DCs are not well understood. Monocyte-derived DCs at different stages of maturation were stimulated with IFN-beta and DC-phenotype and stimulatory function were measured. IFN-beta inhibited the development of DCs at early stages but enhanced DC maturation. Moreover, IFN-beta enhanced the capacity of DCs to stimulate autologous T-cells to secrete IL-13, IL-10 and IL-5. Thus, IFN-beta has both immunostimulatory and immunosuppressive effects on DCs depending on the stage of maturation. |
| Databáze: | OpenAIRE |
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