Antioxidant activity and antitumor activity (in vitro) of xyloglucan selenious ester and surfated xyloglucan
| Autor: | Yu Cao, Isao Ikeda |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Antioxidant
medicine.medical_treatment Antineoplastic Agents Polysaccharide Biochemistry Antioxidants Oxidative damage Selenium chemistry.chemical_compound Sulfation Structural Biology Cell Line Tumor Spectroscopy Fourier Transform Infrared medicine Humans Glucans Molecular Biology Antitumor activity chemistry.chemical_classification Sulfates Chemical modification Esters Free Radical Scavengers General Medicine In vitro Xyloglucan chemistry Spectrophotometry Ultraviolet Xylans Drug Screening Assays Antitumor |
| Zdroj: | International Journal of Biological Macromolecules. 45:231-235 |
| ISSN: | 0141-8130 |
| DOI: | 10.1016/j.ijbiomac.2009.05.007 |
| Popis: | Two kinds of xyloglucan derivatives (xyloglucan selenious ester and sulfated xyloglucan) were prepared and evaluated on antioxidant activity and antitumor activity. Compared with xyloglucan, xyloglucan derivatives have new bioactivity against oxidative damage and tumor. Furthermore, xyloglucan selenious ester is more potent than sulfated xyloglucan at antioxidant activity and antitumor activity in vitro. The current data suggest for the first time that selenition of xyloglucan significantly increases its bioactivity and the chemical modification of polysaccharide may allow the preparation of derivatives with new properties and a variety of applications. |
| Databáze: | OpenAIRE |
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