VACCINES. A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells
| Autor: | Omid C. Farokhzad, Mario Perro, Robert Langer, Jeremy Yethon, Andrew M. Tager, Andrew J. Olive, Pamela Basto, Aleksandar F. Radovic-Moreno, Vladimir Vrbanac, Michael N. Starnbach, Georg Stary, Ulrich H. von Andrian, David Alvarez, David C. Gondek, Jinjun Shi |
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| Rok vydání: | 2015 |
| Předmět: |
Ultraviolet Rays
medicine.medical_treatment Chlamydia trachomatis Biology CD8-Positive T-Lymphocytes medicine.disease_cause Mice Adjuvants Immunologic Antigens CD T-Lymphocyte Subsets medicine Ultraviolet light Animals Mice Inbred BALB C Multidisciplinary Mucous Membrane CD11 Antigens Uterus Vaccination Mucous membrane Dendritic Cells Chlamydia Infections Th1 Cells Bacterial vaccine Mice Inbred C57BL medicine.anatomical_structure Immunization Vaccines Inactivated Immunology Bacterial Vaccines Nanoparticles Female Memory T cell Adjuvant Immunologic Memory Integrin alpha Chains |
| Zdroj: | Science (New York, N.Y.). 348(6241) |
| ISSN: | 1095-9203 |
| Popis: | The right combination for protection Despite its prevalence, no vaccine exists to protect against infection with the sexually transmitted bacterium Chlamydia trachomatis . Stary et al. now report on one potential vaccine candidate (see the Perspective by Brunham). Vaccinating with an ultraviolet light-inactivated C. trachomatis linked to adjuvant-containing charged nanoparticles protected female conventional and humanized mice against C. trachomatis infection. The vaccine conferred protection only when delivered through mucosal routes. Protection relied on targeting the bacteria to a particular population of immunogenic dendritic cells and inducing memory T cells that resided in the female genital tract. Science , this issue 10.1126/science.aaa8205 ; see also p. 1322 |
| Databáze: | OpenAIRE |
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