Serosurveillance study on transmission of H5N1 virus during a 2006 avian influenza epidemic
| Autor: | Resul Yilmaz, M. G. Kurtoglu, Inci Yildirim, Y. Laleli, Ahmet Faik Oner, Mehmet Ceyhan, B. Ozkan, N. Uyar, Bruno Lina, Hasan Tezer, Olivier Ferraris, M. A. Torunoglu, Selim Badur, T. Buzgan, Emilie Frobert, M. Bouscambert-Duchamp |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Adolescent Turkey Epidemiology Orthomyxoviridae Enzyme-Linked Immunosorbent Assay Biology Antibodies Viral medicine.disease_cause Polymerase Chain Reaction Poultry Disease Outbreaks Serology Neutralization Tests Influenza Human Influenza A virus medicine Animals Humans Microneutralization Assay Seroprevalence Child Aged Subclinical infection Influenza A Virus H5N1 Subtype Infant Outbreak Middle Aged biology.organism_classification Virology Influenza A virus subtype H5N1 Infectious Diseases Child Preschool Influenza in Birds Female |
| Zdroj: | Epidemiology and Infection. 138:1274-1280 |
| ISSN: | 1469-4409 0950-2688 |
| DOI: | 10.1017/s095026880999166x |
| Popis: | SUMMARYIn 2006 an outbreak of avian influenza A(H5N1) in Turkey caused 12 human infections, including four deaths. We conducted a serological survey to determine the extent of subclinical infection caused by the outbreak. Single serum samples were collected from five individuals with avian influenza whose nasopharyngeal swabs tested positive for H5 RNA by polymerase chain reaction, 28 family contacts of the cases, 95 poultry cullers, 75 individuals known to have had contact with diseased chickens and 81 individuals living in the region with no known contact with infected chickens and/or patients. Paired serum samples were collected from 97 healthcare workers. All sera were tested for the presence of neutralizing antibodies by enzyme-linked immunoassay, haemagglutination inhibition and microneutralization assays. Only one serum sample, from a parent of an avian influenza patient, tested positive for H5N1 by microneutralization assay. This survey shows that there was minimal subclinical H5N1 infection among contacts of human cases and infected poultry in Turkey in 2006. Further, the low rate of subclinical infection following contact with diseased poultry gave further support to the reported low infectivity of the virus. |
| Databáze: | OpenAIRE |
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