Toxicity of cadmium in musculoskeletal diseases
| Autor: | Karina Martínez-Flores, Carlos Landa-Solís, Carlos Alberto Lozada-Pérez, Y. Zamudio Cuevas, Gabriela Angélica Martínez-Nava, María Concepción Gutiérrez-Ruiz, E. Rojas del Castillo, Alberto López-Reyes, Javier Fernández-Torres, D. Reyes-Hinojosa, Anell Olivos-Meza |
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| Rok vydání: | 2019 |
| Předmět: |
Health
Toxicology and Mutagenesis Osteoporosis Inflammation 010501 environmental sciences Toxicology medicine.disease_cause 01 natural sciences Bone resorption Superoxide dismutase 03 medical and health sciences medicine Animals Humans Musculoskeletal Diseases 030304 developmental biology 0105 earth and related environmental sciences Pharmacology 0303 health sciences biology business.industry Citrullination General Medicine Environmental Exposure medicine.disease Rheumatoid arthritis Toxicity Immunology biology.protein Environmental Pollutants medicine.symptom business Oxidative stress Cadmium |
| Zdroj: | Environmental toxicology and pharmacology. 72 |
| ISSN: | 1872-7077 |
| Popis: | Epidemiological studies have reported that exposure to toxic metals like cadmium (Cd) may promote the development of musculoskeletal diseases, such as osteoporosis, rheumatoid arthritis (RA), and osteoarthritis (OA), among others. The objective of this review is to summarize the molecular mechanisms of inflammation and oxidative stress activated by Cd at the bone level, particularly in osteoporosis, RA, and OA. Cadmium can increase bone resorption, affect the activity of osteoclasts and calcium (Ca) absorption, and impair kidney function, which favors the development of osteoporosis. In the case of RA, Cd interferes with the activity of antioxidant proteins, like superoxide dismutase (SOD) and catalase (CAT). It also promotes an inflammatory state, inducing the process of citrullination, which affects the proteins of immune response. On the other hand, accumulation of Cd in the tissues and blood of smokers has been related to the development of some musculoskeletal diseases. Therefore, knowing the negative impact of Cd toxicity at the articular level can help understand the damage mechanisms it produces, leading to the development of such diseases. |
| Databáze: | OpenAIRE |
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