Glycosylated hemoglobin levels are associated with cardiovascular events in nondiabetic peritoneal dialysis patients
| Autor: | Fatih Kircelli, Gulay Asci, Meltem Sezis Demirci, Timur Köse, Hamad Dheir, Huseyin Toz, Muhittin Ertilav, Ercan Ok, Mehmet Ozkahya |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty endocrine system diseases medicine.medical_treatment Population Gastroenterology Disease-Free Survival Peritoneal dialysis Young Adult Risk Factors Internal medicine medicine Humans Longitudinal Studies Prospective Studies Renal Insufficiency Chronic Risk factor Young adult Prospective cohort study education Dialysis Aged Proportional Hazards Models Glycated Hemoglobin education.field_of_study biology Proportional hazards model business.industry C-reactive protein nutritional and metabolic diseases Middle Aged C-Reactive Protein Endocrinology Cardiovascular Diseases Nephrology biology.protein Female business Peritoneal Dialysis |
| Zdroj: | Journal of Nephrology. 25:107-112 |
| ISSN: | 1121-8428 |
| DOI: | 10.5301/jn.2011.8350 |
| Popis: | Background: High glycosylated hemoglobin (HbA 1c ) levels are recognized as a risk factor for cardiovas- cular disease in the diabetic dialysis population. However, it is not known whether this also applies to nondiabetic dialysis patients. We prospectively inves- tigated the association between HbA 1c levels and new cardiovascular events in nondiabetic patients treated with peritoneal dialysis. Methods: Eighty nondiabetic patients who had been on peritoneal dialysis treatment were prospectively followed for 5 years. HbA 1c levels were measured at baseline and every 3 months. Fatal and nonfatal cardiovascular events were assessed during the fol- low-up. Results: Mean age was 48.5 ± 15.2 years; 51% were male. Baseline HbA 1c level was 5.46% ± 0.41% (range 4.6%-6.3%). Mean HbA 1c was 5.44% ± 0.31% (range 4.8%-6.3%) during the study, and positively correlated with age and high-sensitivity C-reactive protein. Twen- ty fatal and nonfatal cardiovascular events were ob- served during a mean 41.8 ± 7.1 months of follow-up. Event-free survival was better in patients with HbA 1c levels |
| Databáze: | OpenAIRE |
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