Factors affecting progression-free survival in non-HIV-related Kaposi sarcoma
| Autor: | Hamza Ugur Bozbey, Fatma Sen, Sidika Kurul, Sezai Vatansever, Ethem Nezih Oral, Adnan Aydiner, Bahtiyar Toz, Pinar Saip, Ahmet Kizir, Hasan Karanlik, Esra Sağlam, Makbule Tambas, Rumeysa Ciftci, Leyla Kilic |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Treatment response medicine.medical_treatment HIV Infections Dermatology Disease Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Neoplasm Humans Progression-free survival Sarcoma Kaposi Aged Retrospective Studies Aged 80 and over Chemotherapy business.industry Immunosuppression Middle Aged medicine.disease Surgery Radiation therapy 030104 developmental biology 030220 oncology & carcinogenesis Multivariate Analysis Disease Progression Female Sarcoma business |
| Zdroj: | The Journal of dermatological treatment. 27(3) |
| ISSN: | 1471-1753 |
| Popis: | Background: Non-HIV related Kaposi sarcoma (NHKS) is a rare indolent neoplasm which is more common around Mediterranean origin. Data concerning factors that influence progression-free survival (PFS) for NHKS are insufficient. The purpose of present retrospective analysis was to distinguish the factors affecting PFS in patients with NHKS. Methods: A hundred and twenty-eight consecutive patients with NHKS who were treated or observed between 1997 and 2014 at Istanbul University Institute of Oncology were included into the study. Treatment response and progression definitions were determined according to different treatment modalities administered at first line. Results: Majority of patients were male (n = 97, 75.8%). Median age of the whole group was 66 years (28-85). Of the patients, 15 patients were immunosuppressant, whereas 113 patients had no disease that caused immunosuppression. Patients were treated with local excision (n = 57, 44.5%), chemotherapy (n = 32, 25.0%) and/or radiotherapy (n = 13, 10.2%) or observed without treatment (n = 26, 20.3%). At a median follow-up of 28 months, 71 (55.5%) patients had progression, while 3 patients (2.3%) died of NHKS. On univariate analysis, patients who had hypertension (HT) had poorer PFS compared with others (19 +/- 12 versus 41 +/- 22 months; p = 0.03), whereas plaque formation was associated with better outcome (25 +/- 9 versus 54 +/- 12 months; p = 0.03). In addition, heavy smoking (>= 40 pack-years) had a borderline significance regarding better PFS time (23 +/- 24 versus 45 +/- 38 months, p = 0.06). On multivariate analysis, none of factors evaluated had any impact on PFS. Conclusions: HT was correlated with poorer outcome among NHKS patients. Patients with plaque formation and >= 40 pack-years of smoking had better PFS than others. |
| Databáze: | OpenAIRE |
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