The Personal Genome Project-UK: an open access resource of human multi-omics data
Autor: | Amy P. Webster, Elizabeth Larose Cadieux, Javier Herrero, José Afonso Guerra-Assunção, Alison Berner, Stephan Beck, Lucia Conde, Rifat Hamoudi, Vitaly Voloshin, Olga Chervova, Ismail Moghul, Yuan Tian |
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Rok vydání: | 2019 |
Předmět: |
0303 health sciences
Computer science business.industry Genomics Cloud computing Sample (statistics) Data science Transcriptome Personal Genome Project 03 medical and health sciences 0302 clinical medicine Resource (project management) 030220 oncology & carcinogenesis Data integrity business 030304 developmental biology |
Popis: | Integrative analysis of multi-omics data is a powerful approach for gaining functional insights into biological and medical processes. Conducting these multifaceted analyses on human samples is often complicated by the fact that the raw sequencing output is rarely available under open access. The Personal Genome Project UK (PGP-UK) is one of few resources that recruits its participants under open consent and makes the resulting multi-omics data freely and openly available. As part of this resource, we describe the PGP-UK multi-omics reference panel consisting of ten genomic, methylomic and transcriptomic data. Specifically, we outline the data processing, quality control and validation procedures which were implemented to ensure data integrity and exclude sample mix-ups. In addition, we provide a REST API to facilitate the download of the entire PGP-UK dataset. The data are also available from two cloud-based environments, providing platforms for free integrated analysis. In conclusion, the genotype-validated PGP-UK multi-omics human reference panel described here provides a valuable new open access resource for integrated analyses in support of personal and medical genomics. |
Databáze: | OpenAIRE |
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