Anti-α-enolase antibody combined with β2 microglobulin evaluated the incidence of nephritis in systemic lupus erythematosus patients

Autor:	Wei Wang, L Chen, Kang Chen, Yuli Huang, Feng Huang, Yanling Feng, Zuo-Feng Xu
Rok vydání:	2019
Předmět:	0301 basic medicine Adult Male Enzyme-Linked Immunosorbent Assay α enolase 03 medical and health sciences 0302 clinical medicine Rheumatology Predictive Value of Tests medicine Humans 030203 arthritis & rheumatology biology Beta-2 microglobulin business.industry Incidence (epidemiology) Middle Aged medicine.disease Lupus Nephritis 030104 developmental biology Area Under Curve Case-Control Studies Phosphopyruvate Hydratase Immunology biology.protein Female Antibody business beta 2-Microglobulin Nephritis Biomarkers
Zdroj:	Lupus. 28(3)
ISSN:	1477-0962
Popis:	Objective Anti–α-enolase antibody (Ab) combined with β2 microglobulin (β2-MG) were investigated to predict the incidence of nephritis in systemic lupus erythematosus (SLE) patients. Methods Levels of serum anti–α-enolase Ab and urinary β2-MG were detected in 115 SLE patients, 29 SLE patients with nephritis and 70 healthy controls by ELISA and immunoturbidimetry, respectively. Furthermore, the correlation between anti–α-enolase Ab combined with β2-MG and the incidence of nephritis in SLE patients was evaluated by correlation analysis. Results The optical density value of serum anti–α-enolase Ab in SLE patients with nephritis (0.84) was greatly increased compared with SLE patients (0.76) or healthy controls (0.54). Moreover, the levels of urinary β2-MG in SLE patients with nephritis (6.75 mg/L) were increased compared with SLE patients (3.45 mg/L) or healthy controls (1.48 mg/L). There was a positive correlation between the level of anti–α-enolase Ab and β2-MG ( r = 0.754). Furthermore, anti–α-enolase Ab combined with β2-MG for evaluating the incidence of nephritis in SLE patients had the best assessment of the effectiveness (area under the receiver operating characteristic curve (AUC): 92.7%) compared with only anti–α-enolase Ab (AUC: 80.9%) or β2-MG (AUC: 84.5%). Conclusion These data suggested that anti–α-enolase Ab may be a potential indicator for the prediction of nephritis in SLE patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9587cb178a8966644f086c18ee9ec3b https://pubmed.ncbi.nlm.nih.gov/30813870 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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