Functional activity of P-glycoprotein in lymphocytes of patients with lymphoproliferative diseases
| Autor: | N. P. Domnikova, O. V. Mukhin, E. V. Mel’nikova, E. V. Vorontsova, A. Yu. Grishanova, V. V. Lyakhovich |
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| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_treatment
Lymphoproliferative disorders Rhodamine 123 General Biochemistry Genetics and Molecular Biology Flow cytometry chemistry.chemical_compound Medicine Humans ATP Binding Cassette Transporter Subfamily B Member 1 Lymphocytes P-glycoprotein Chemotherapy biology medicine.diagnostic_test business.industry Case-control study General Medicine medicine.disease Flow Cytometry Lymphoproliferative Disorders Multiple drug resistance chemistry Drug Resistance Neoplasm Case-Control Studies Immunology biology.protein Functional activity business |
| Zdroj: | Bulletin of experimental biology and medicine. 136(5) |
| ISSN: | 0007-4888 |
| Popis: | Functional activity of P-glycoprotein in lymphocytes of patients with lymphoproliferative diseases was studied using rhodamine 123. Functional activity of P-glycoprotein in patients receiving a course of chemotherapy was lower than in controls. P-glycoprotein activity was higher in patients receiving more aggressive therapy. Initially activity of P-glycoprotein was higher in patients who did not respond to chemotherapy in comparison with those whose clinical status improved after a course of chemotherapy. |
| Databáze: | OpenAIRE |
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