Dual-Energy Computed Tomography-Based Iodine Quantitation for Response Evaluation of Lung Cancers to Chemoradiotherapy/Radiotherapy: A Comparison With Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography-Based Positron Emission Tomography/Computed Tomography Response Evaluation Criterion in Solid Tumors
| Autor: | Weiqiang Ge, Weihao Zhai, Min Fang, Cheng Li, Xiangpeng Zheng, Yuxin Jiao, Xi Tang, Libo Zhang, Yanping Ren, Yanqing Hua, Wei He |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Lung Neoplasms Radiography medicine.medical_treatment chemistry.chemical_element Iodine 030218 nuclear medicine & medical imaging Radiography Dual-Energy Scanned Projection 03 medical and health sciences 0302 clinical medicine Fluorodeoxyglucose F18 Positron Emission Tomography Computed Tomography medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Lung Aged Fluorodeoxyglucose Aged 80 and over medicine.diagnostic_test business.industry Dual-Energy Computed Tomography Chemoradiotherapy Middle Aged Radiation therapy Treatment Outcome chemistry Positron emission tomography 030220 oncology & carcinogenesis Female Tomography Radiopharmaceuticals business Nuclear medicine Tomography X-Ray Computed medicine.drug |
| Zdroj: | Journal of computer assisted tomography. 42(4) |
| ISSN: | 1532-3145 |
| Popis: | The objective of this study was to investigate the correlation between dual-energy computed tomography (DECT)-based iodine quantitation and fluorine-18 fluorodeoxyglucose (F-FDG) positron emission tomography (PET)/computed tomography (CT) imaging for response evaluation of lung cancers to treatment.In this prospective study, a total of 32 pairs of DECT and F-FDG PET/CT imaging acquired consecutively from 13 patients with primary or metastatic lung cancers receiving either radiotherapy alone or chemoradiotherapy were analyzed. Imaging examinations were performed before, immediately, and no later than 6 months after treatment for response evaluation. Iodine-related parameters including the total iodine uptake (TIU) and vital volume (VIV) from DECT and metabolic metrics such as the standardized uptake value normalized to lean body mass (SULpeak), metabolic tumor volume (MTV), and the total lesion glycolysis (TLG) from F-FDG-PET/CT were generated and measured by semiautomatic approaches. Dual-energy CT and PET/CT metrics were calculated and followed up with comparison with response evaluation criteria in solid tumors (RECIST).Analysis of pretreatment imaging data revealed a strong correlation between DECT metrics (RECIST, TIU, and VIV) and F-FDG PET/CT metrics (MTV, TLG) with coefficients of R ranging from 0.86 to 0.90 (P0.01). With the delivery of treatment, all measured DECT and PET/CT metrics significantly decreased whereas the descending amplitude in RECIST was significantly smaller than that of the remaining parameters (P0.05). During follow-up examinations, both metrics followed a similar changing pattern. Overall, strong consistency was found between RECIST, TIU, VIV and SULpeak, MTV, TLG (R covers 0.78-0.96, P0.05).Semiautomatic iodine-related quantitation in DECT correlated well with metabolism-based measurements in F-FDG PET/CT, suggesting that DECT-based iodine quantitation might be a feasible substitute for assessment of lung cancer response to chemoradiotherapy/radiotherapy with comparison with F-FDG PET/CT. |
| Databáze: | OpenAIRE |
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