The BOLD effect of interictal spike activity in childhood occipital lobe epilepsy

Autor: Alberto Leal, Ana I. Dias, Constança Jordão, Mário Forjaz Secca, José Pedro Vieira
Rok vydání: 2006
Předmět:
Male
Occipital Lobe/physiopathology
Epilepsies
Partial/diagnosis
Adolescent
Cerebral Cortex/physiopathology
Electroencephalography/methods
Posterior parietal cortex
Late onset
HDE NEU PED
Electroencephalography
EEG-fMRI
030218 nuclear medicine & medical imaging
Magnetic Resonance Imaging/methods
03 medical and health sciences
Epilepsy
0302 clinical medicine
Cortex (anatomy)
Parietal Lobe
Brain Mapping/methods
medicine
Humans
Ictal
Parietal Lobe/physiopathology
Epilepsies
Partial/blood
Age of Onset
Child
Cerebral Cortex
Brain Mapping
medicine.diagnostic_test
medicine.disease
Magnetic Resonance Imaging
Temporal Lobe
Oxygen
medicine.anatomical_structure
Epilepsies
Partial/physiopathology
Neurology
Female
Neurology (clinical)
Epilepsies
Partial
Occipital Lobe
Occipital lobe
Psychology
Neuroscience
030217 neurology & neurosurgery
Zdroj: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
ISSN: 0013-9580
Popis: Summary: Purpose: Occipital lobe epilepsy (OLE) presents in childhood with different manifestations, age of onset and EEG features that form distinct syndromes. The ictal clinical symptoms are difficult to correlate with onset in particular areas in the occipital lobes, and the EEG recordings have not been able to overcome this limitation. The mapping of epileptogenic cortical regions in OLE remains therefore an important goal in our understanding of these syndromes. Methods: In this work, three patients with two types of idiopathic childhood OLE were studied with EEG source analysis and also with mapping of the BOLD effect associated with spikes in simultaneous EEG/fMRI recordings. Results: Two patients with late onset OLE provided EEG source localizations in the lateral parietal cortex and in the medial occipital areas. The BOLD activations were more consistent and restricted to the medial parietal-occipital cortex in both cases. One patient with photosensitive idiopathic OLE presented with dipole sources in the medial parietal cortex, but the BOLD activations were widespread over inferior and bilateral occipital areas and also posterior temporal ones. There was little spatial overlap between the EEG and BOLD results, but the localizations suggested by the latter are more consistent with the ictal clinical manifestations of each type of epileptic syndrome. Conclusions: Overall, the BOLD effect associated with interictal spikes maps epileptogenic areas to different localizations than the ones suggested by EEG source analysis. These maps are similar in two patients with late onset idiopathic OLE, but different from a case of photosensitive idiopathic OLE.
Databáze: OpenAIRE
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