Altered Gut Microbiota in a Mouse Model of Alzheimer's Disease
| Autor: | Changhua Shi, Lan Huang, Yunlin Han, Xia Xiayu, Yanfeng Xu, Nan Song, Rui Zhou, Chuan Qin, Ying Wang, Wei Chen, Ling Zhang, Xinjing Fu, Hua Zhu |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Aging Mice Transgenic Disease Gut flora digestive system 03 medical and health sciences Feces 0302 clinical medicine Alzheimer Disease Animals Microbiome Specific-pathogen-free biology General Neuroscience Short-chain fatty acid Computational Biology General Medicine biology.organism_classification Fatty Acids Volatile Gastrointestinal Microbiome Intestines Psychiatry and Mental health Clinical Psychology Metabolic pathway Disease Models Animal 030104 developmental biology Time course Immunology Geriatrics and Gerontology 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's disease : JAD. 60(4) |
| ISSN: | 1875-8908 |
| Popis: | The topic of gut microbiota is currently attracting considerable interest as a potential factor in Alzheimer's disease (AD). However, the extent and time course of alterations in the gut microbiota, and their effects on AD pathology remain uncertain. Herein, we compared the fecal microbiomes and fecal short chain fatty acid composition (SCFAs) between wild-type and AD model mice at different ages under strictly controlled specific pathogen free conditions, and also conducted microscopic investigations of intestinal structures. Our results showed that the microbiota composition and diversity were perturbed and the level of SCFAs was reduced in AD mice, predicting alterations in more than 30 metabolic pathways, which may be associated with amyloid deposition and ultrastructural abnormalities in AD mouse intestine. These findings indicate that AD pathology might not only affect brain function directly, but also exacerbate cognitive deficits through reducing the level of SCFAs via alterations of gut microbiota induced by intestinal amyloid deposition. Our data may support a role of gut microbiota, and suggest a novel route for therapeutic intervention in AD. |
| Databáze: | OpenAIRE |
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