Standardized Mississippi Protocol Treatment of 190 Patients with HELLP Syndrome: Slowing Disease Progression and Preventing New Major Maternal Morbidity
| Autor: | Warren L. May, Kiran Tam Tam, Marc Parrish, James N. Martin, Justin Brewer, Julie Cushman, Sharon D. Keiser, Michelle Y. Owens |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
HELLP Syndrome medicine.medical_specialty HELLP syndrome Maternal morbidity Disease Preeclampsia Young Adult Clinical Protocols Pregnancy Internal medicine Internal Medicine medicine Humans Prospective Studies Stroke Academic Medical Centers business.industry Obstetrics and Gynecology medicine.disease Hemolysis Surgery Treatment Outcome Blood pressure Disease Progression Female Maternal death business |
| Zdroj: | Hypertension in Pregnancy. 31:79-90 |
| ISSN: | 1525-6065 1064-1955 |
| DOI: | 10.3109/10641955.2010.525277 |
| Popis: | Objective. To evaluate the effectiveness of the Mississippi Protocol (MP) to treat HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome. Methods. Uniform early initiation of MP (corticosteroids, magnesium sulfate, systolic blood pressure control) was studied prospectively in patients admitted with severe preeclampsia/class 1 or class 2 HELLP syndrome. Results. One hundred and ninety patients between 2000 and 2007 received MP without suffering maternal death, stroke, or liver rupture. Only 39 of 163 patients (24%) not class 1 when MP began progressed to class 1 disease; only 18.2% of class 1 and 2.4% of class 2 subsequently developed major maternal morbidity. Conclusion. Early initiation of MP inhibits HELLP syndrome disease progression and severity. |
| Databáze: | OpenAIRE |
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