Efficacy of ulipristal acetate in women with fibroid induced menorrhagia: A systematic review and meta-analysis
| Autor: | Amudha Poobalan, Stavroula Kastora, Emma Barnott, Alison Margaret Jack, Tamara Robinson-Burke, Georgios Kounidas, Dale Morgan, Alexandra Gould, Grace Urquhart, Lydia Black |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Funnel plot Norpregnadienes MEDLINE Placebo 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Contraceptive Agents Internal medicine Ulipristal acetate medicine Humans Adverse effect Menorrhagia 030219 obstetrics & reproductive medicine Leiomyoma business.industry Obstetrics and Gynecology Publication bias female genital diseases and pregnancy complications Study heterogeneity Reproductive Medicine chemistry 030220 oncology & carcinogenesis Meta-analysis Uterine Neoplasms Female business |
| Zdroj: | Journal of gynecology obstetrics and human reproduction. 50(9) |
| ISSN: | 2468-7847 |
| Popis: | Aim To evaluate the efficacy of UPA in women with fibroid induced menorrhagia. Methods Embase, MEDLINE, CAB Abstracts, Cochrane Central Register of Controlled Trials, PsychInfo were searched up to 18th May 2020 and updated on 7th February 2021. Randomised controlled trials evaluating the efficacy of UPA in women with fibroid induced menorrhagia were included in the study. Results Two authors independently reviewed and extracted the study data. Statistical heterogeneity was quantified using I2 statistics. Publication bias and data asymmetry was assessed by funnel plots. A meta-analysis was conducted where appropriate. Six studies were eligible for inclusion. UPA (5 mg and 10 mg) achieved statistically significant amenorrhoeic outcome when compared to placebo (p Conclusions This review demonstrates the efficacy of UPA in achieving amenorrhoea in women with fibroid induced menorrhagia. However, the favourable dose of UPA remains inconclusive when AE profile is taken into account. Evidence remains obscure regarding liver damage and further research is warranted to attain a conclusive outcome. |
| Databáze: | OpenAIRE |
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