XeCl laser-induced fluorescence of atherosclerotic arteries. Spectral similarities between lipid-rich lesions and peroxidized lipoproteins
| Autor: | Steven L. Jacques, J H Nguy, Roland A. Sauerbrey, G.H. Pettit, Alexander A. Oraevsky, Frank K. Tittel, P D Henry |
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| Rok vydání: | 1993 |
| Předmět: |
Xenon
Physiology Fluorescence spectrometry Lipoproteins VLDL Fluorescence spectroscopy Lipid peroxidation chemistry.chemical_compound Chlorides Animals Humans Laser-induced fluorescence Aorta Foam cell Angioscopes Cholesterol Lasers Angioscopy Lipoproteins LDL Spectrometry Fluorescence Biochemistry chemistry Low-density lipoprotein Biophysics lipids (amino acids peptides and proteins) Lipid Peroxidation Rabbits Cardiology and Cardiovascular Medicine Lipoprotein |
| Zdroj: | Circulation Research. 72:84-90 |
| ISSN: | 1524-4571 0009-7330 |
| DOI: | 10.1161/01.res.72.1.84 |
| Popis: | Autofluorescence spectroscopy of arterial surfaces provides information about the distribution and composition of atherosclerotic plaques. The aim of the study was to determine whether accumulation of peroxidized lipoproteins in arterial walls, a process postulated to play a role in initiating atherosclerotic changes, can be demonstrated by fluorescence spectroscopy. XeCl excimer laser (308 nm)-induced fluorescence of human aortas containing early lipid-rich noncollagenous lesions exhibited marked red shifts and broadening of the fluorescence spectra compared with spectra from nonatherosclerotic aortas. Similar profiles were observed in spectra obtained from oxidatively modified low density lipoprotein but not native low density lipoprotein. In hypercholesterolemic rabbits with early foam cell lesions, spectral shifts resembled those of oxidized beta-very low density lipoprotein, the major lipoprotein accumulating in arteries of rabbits fed cholesterol. XeCl laser-fluorescence spectroscopy of arterial surfaces may be useful for the identification of arteries accumulating modified lipoproteins (oxidized low density lipoprotein), a chemical change indicative of atherosclerosis in its early and probably reversible stages. |
| Databáze: | OpenAIRE |
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