Pathophysiology and treatment of atherosclerosis
| Autor: | Mathijs C. Bodde, Joop Jukema, S. C. Bergheanu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Lipoprotein modification Review Article 030204 cardiovascular system & hematology Bioinformatics 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Medicine 030212 general & internal medicine Hypercholesterolaemia Lipoprotein cholesterol Future perspective business.industry Low-density lipoprotein Statins Atherosclerotic disease Atherosclerosis Cardiovascular disease Pathophysiology Clinical trial Endocrinology chemistry lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine business Proprotein convertase subtilisin/kexin type-9 Lipoprotein |
| Zdroj: | Netherlands Heart Journal, 25(4), 231-242 Netherlands Heart Journal |
| ISSN: | 1876-6250 1568-5888 |
| DOI: | 10.1007/s12471-017-0959-2 |
| Popis: | Recent years have brought a significant amount of new results in the field of atherosclerosis. A better understanding of the role of different lipoprotein particles in the formation of atherosclerotic plaques is now possible. Recent cardiovascular clinical trials have also shed more light upon the efficacy and safety of novel compounds targeting the main pathways of atherosclerosis and its cardiovascular complications. In this review, we first provide a background consisting of the current understanding of the pathophysiology and treatment of atherosclerotic disease, followed by our future perspectives on several novel classes of drugs that target atherosclerosis. The focus of this update is on the pathophysiology and medical interventions of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG) and lipoprotein(a) (Lp(a)). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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