Presence of mother prompts dissociation of sickness behavior, fever, and hypothalamic gene expression in lipopolysaccharide‐injected guinea pig pups
| Autor: | Joshua D. Sensenbaugh, Andrea L. Molina, Terrence Deak, Michael B. Hennessy, Patricia A. Schiml |
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| Rok vydání: | 2020 |
| Předmět: |
Lipopolysaccharides
Male Fever Lipopolysaccharide Guinea Pigs Hypothalamus Gene Expression Mothers Social stimuli Article Guinea pig Piloerection 03 medical and health sciences Behavioral Neuroscience chemistry.chemical_compound 0302 clinical medicine Developmental Neuroscience Gene expression Developmental and Educational Psychology Animals Medicine 0501 psychology and cognitive sciences Sickness behavior Illness Behavior Host resistance Behavior Animal business.industry 05 social sciences Fear Social processes chemistry Immunology Female business 030217 neurology & neurosurgery 050104 developmental & child psychology Developmental Biology |
| Zdroj: | Dev Psychobiol |
| ISSN: | 1098-2302 0012-1630 |
| DOI: | 10.1002/dev.21962 |
| Popis: | During infection, sickness behaviors, such as a hunched stance with piloerection, can facilitate host resistance by supporting the generation and maintenance of fever. Fever, in turn, is mediated by hypothalamic neuroimmune signaling. Sickness behaviors, however, can also be influenced by social stimuli. In the present study, guinea pig pups were injected with lipopolysaccharide to simulate a bacterial infection and then exposed to a novel, threatening environment while either with their mother or alone. We found the presence of the mother suppressed sickness behavior, but enhanced fever, and had no measureable effect on gene expression of hypothalamic mediators of fever. This 3-way dissociation induced by the mother’s presence is interpreted in terms of the differential adaptive consequences of behavioral and febrile responses for pups in this situation. The results contribute to a growing literature linking immunological and social processes. |
| Databáze: | OpenAIRE |
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