Chemical structures of plant hydrolyzable tannins reveal their in vitro activity against egg hatching and motility of Haemonchus contortus nematodes
| Autor: | Jeffrey R. Ahern, Maarit Karonen, Bruno Payré, Juha-Pekka Salminen, Nicolas Baert, Hervé Hoste, Marica T. Engström |
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| Přispěvatelé: | University of Turku, Université de Toulouse (UT), Interactions hôtes-agents pathogènes [Toulouse] (IHAP), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT), Academy of Finland [258992, 251388], Svenska tekniska vetenskapsakademien i Finland (STV), Strategic Research Grant (Ecological Interactions), European Project: 289377,EC:FP7:PEOPLE,FP7-PEOPLE-2011-ITN,LEGUMEPLUS(2012), Université Fédérale Toulouse Midi-Pyrénées, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
nematode [SDV]Life Sciences [q-bio] Hydrolyzable Tannin tannin Structure-Activity Relationship 03 medical and health sciences chemistry.chemical_compound Haemonchus contortus Botany hydrolyzable tannin medicine bioactive plant Animals Tannin Gallic acid Anthelmintic ta116 Ovum chemistry.chemical_classification Molecular Structure biology Plant Extracts Hatching Antinematodal Agents General Chemistry Plants 030108 mycology & parasitology biology.organism_classification Hydrolyzable Tannins polyphenol 030104 developmental biology Nematode Biochemistry chemistry Polyphenol Haemonchus General Agricultural and Biological Sciences natural anthelmintic medicine.drug |
| Zdroj: | Journal of Agricultural and Food Chemistry Journal of Agricultural and Food Chemistry, 2016, 64 (4), pp.840-851. ⟨10.1021/acs.jafc.5b05691⟩ Journal of Agricultural and Food Chemistry, American Chemical Society, 2016, 64 (4), pp.840-851. ⟨10.1021/acs.jafc.5b05691⟩ |
| ISSN: | 0021-8561 1520-5118 |
| Popis: | International audience; The use of synthetic drugs against gastrointestinal nematodes of ruminants has led to a situation where resistance to anthelmintics is widespread, and there is an urgent need for alternative solutions for parasite control. One promising approach is to use polyphenol-rich bioactive plants in animal feeds as natural anthelmintics. In the present work, the in vitro activity of a series of 33 hydrolyzable tannins (HTs) and their hydrolysis product, gallic acid, against egg hatching and motility of L1 and L2 stage Haemonchus contortus larvae was studied. The effect of the selected compounds on egg and larval structure was further studied by scanning electron microscopy. The results indicated clear relationships between HT structure and anthelmintic activity. While HT size, overall flexibility, the types and numbers of functional groups, together with the linkage types between monomeric HTs affected the activity differently, the optimal structure was found with pentagalloylglucose. |
| Databáze: | OpenAIRE |
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