A new periplogenin cardenolide from the seeds of Antiaris toxicaria

Autor:	Cheng Liu, Yu-Ling Wu, Chen Jing, Xiuli Wu, Hou-Gang Li, Liu Hetao, Jianhuan Wang, Xueyan Fu, Rui-Qin Cui
Rok vydání:	2014
Předmět:	Periplogulcoside Stereochemistry Pharmaceutical Science Mass spectrometry Analytical Chemistry HeLa chemistry.chemical_compound Antiaris Drug Discovery Cardenolide Humans Cytotoxicity Nuclear Magnetic Resonance Biomolecular Pharmacology Chromatography biology Molecular Structure Chemistry Plant Extracts Organic Chemistry General Medicine Hep G2 Cells biology.organism_classification Antineoplastic Agents Phytogenic Cardenolides Periplogenin Complementary and alternative medicine Seeds Molecular Medicine Drug Screening Assays Antitumor Two-dimensional nuclear magnetic resonance spectroscopy Drugs Chinese Herbal HeLa Cells
Zdroj:	Journal of Asian natural products research. 16(4)
ISSN:	1477-2213
Popis:	A new periplogenin cardenolide, periplogulcoside (1), together with three known cardenolides, was isolated from the seeds of Antiaris toxicaria. The structure of the new compound was characterized as periplogenin-3-O-β-d-glucopyranosyl-(1 → 4)-β-d-glucopyranoside (1) by spectroscopic methods including 1D and 2D NMR, HR-TOF-MS, and CD spectrometry, and the known compounds were identified by comparison of their NMR and HR-TOF-MS data with those reported in the literature. Compound 1 showed significant cytotoxicity against Hela and HepG-2 cell lines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e946ef6fc4ee6be4ae2ef53819148711 https://pubmed.ncbi.nlm.nih.gov/24597720 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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