APOE genotype influences acquisition and recall following traumatic brain injury
| Autor: | L. Michaels, Sonam Singh, Fiona Crawford, Andres M. Salazar, Laila Abdullah, Robert H. Lipsky, M. Waisman, Melissa J. Freeman, Rodney D. Vanderploeg, Deborah L. Warden, Michael Mullan |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Oncology Apolipoprotein E medicine.medical_specialty Genotype Traumatic brain injury Apolipoprotein E4 Central nervous system disease Apolipoproteins E Internal medicine medicine Humans Alleles Analysis of Variance Chi-Square Distribution Recall Memoria Head injury Middle Aged medicine.disease Brain Injuries Mental Recall Regression Analysis lipids (amino acids peptides and proteins) Neurology (clinical) Analysis of variance Cognition Disorders Psychology Neuroscience |
| Zdroj: | Neurology. 58:1115-1118 |
| ISSN: | 1526-632X 0028-3878 |
| DOI: | 10.1212/wnl.58.7.1115 |
| Popis: | APOE has been demonstrated to influence traumatic brain injury (TBI) outcome. The relationship between APOE genotype and memory following TBI was examined in 110 participants in the Defense and Veterans' Head Injury Program. Memory performance was worse in those who had an APOE epsilon 4 allele (n = 30) than those who did not (n = 80), whereas genotype groups did not differ on demographic or injury variables or on measures of executive functioning. These data support a specific role for the APOE protein in memory outcome following TBI, and suggest an APOE isoform-specific effect on neuronal repair processes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|