Relapse rates and a 10-year follow-up of a 6-week quadruple drug regimen for multibacillary leprosy
| Autor: | S Grillone, S Pattyn |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Mycobacterial diseases
Ofloxacin medicine.medical_specialty medicine.medical_treatment Bacterial diseases Minocycline Clofazimine Recurrence Leprosy Internal medicine medicine Treatment regimen Evaluation Rifampicin General Environmental Science Antibacterial agent Chemotherapy biology business.industry Follow-up biology.organism_classification medicine.disease Surgery Treatment success Regimen Tasa General Earth and Planetary Sciences business medicine.drug |
| Zdroj: | Leprosy Review. 73:245-247 |
| ISSN: | 2162-8807 |
| DOI: | 10.47276/lr.73.3.245 |
| Popis: | Between 1989 and 1993, 136 multibacillary leprosy patients received a 6-week treatment regimen consisting of daily rifampicin 600 mg, ofloxacin 400 mg, clofazimine 100 mg and a weekly dose of 100 mg minocycline. A previous analysis after a mean follow-up of 4-7 years revealed a relapse rate of 2%, involving six late (after more than 5 years of follow-up) relapses. During the following years, 12 more relapses appeared during years 8-9 of follow-up. A mean follow-up period of 5 years is insufficient to evaluate treatment regimens in multibacillary leprosy. The present regimen cannot be recommended. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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