Oxygen in the Tumor Microenvironment: Mathematical and Numerical Modeling
| Autor: | Roberto Chignola, Heiko Rieger, Edoardo Milotti, Thierry Fredrich |
|---|---|
| Přispěvatelé: | A. Birbrair, Milotti, E., Fredrich, T., Chignola, R., Rieger, H. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Cell-based tumor model
Lattice-free model Lattice-free models Cell-based tumor models Numerical simulation Oxygen Tumor hemodynamic Diffusion 0302 clinical medicine Models Neoplasms Darwinian evolution in tumor Numerical simulations Tumor Microenvironment 030212 general & internal medicine Tumor angiogenesi Mathematical model Chemistry Computer modeling Hypoxia (environmental) Cell Hypoxia Radiation therapy medicine.anatomical_structure Darwinian evolution in tumors Blood vessel Human Tumor heterogeneity Numerical modeling chemistry.chemical_element Models Biological Tumor angiogenesis Microcirculation 03 medical and health sciences Tumor cord Tumor hemodynamics Mathematical modeling Tumor cords Tumor growth Tumor hypoxia Tumor metabolism Computer Simulation Humans medicine Tumor microenvironment Biological Biophysics Neoplasm |
| Zdroj: | Advances in Experimental Medicine and Biology ISBN: 9783030430924 |
| Popis: | There are many reasons to try to achieve a good grasp of the distribution of oxygen in the tumor microenvironment. The lack of oxygen - hypoxia - is a main actor in the evolution of tumors and in their growth and appears to be just as important in tumor invasion and metastasis. Mathematical models of the distribution of oxygen in tumors which are based on reaction-diffusion equations provide partial but qualitatively significant descriptions of the measured oxygen concentrations in the tumor microenvironment, especially when they incorporate important elements of the blood vessel network such as the blood vessel size and spatial distribution and the pulsation of local pressure due to blood circulation. Here, we review our mathematical and numerical approaches to the distribution of oxygen that yield insights both on the role of the distribution of blood vessel density and size and on the fluctuations of blood pressure. |
| Databáze: | OpenAIRE |
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