Tracing the LINEs of human evolution
| Autor: | Gary D. Swergold, Adrienne Rubin, Igor V. Ovchinnikov |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
Multidisciplinary
Subfamily Lineage (genetic) DNA Complementary Base Sequence Genotype Hominidae Molecular Sequence Data Retrotransposon Biology Biological Sciences biology.organism_classification Evolution Molecular Mutagenesis Insertional Long Interspersed Nucleotide Elements Human evolution Phylogenetics Evolutionary biology Molecular evolution Animals Humans Human genome Poly A Phylogeny |
| Popis: | The amplification of DNA by LINE-1 (L1) retrotransposons has created a large fraction of the human genome. To better understand their role in human evolution we endeavored to delineate the L1 elements that have amplified since the emergence of the hominid lineage. We used an approach based on shared sequence variants to trace backwards from the currently amplifying Ta subfamily. The newly identified groups of insertions account for much of the molecular evolution of human L1s. We report the identification of a L1 subfamily that amplified both before and after the divergence of humans from our closest extant relatives. Progressively more modern groups of L1s include greater numbers of insertions. Our data are consistent with the hypothesis that the rate of L1 amplification has been increasing during recent human evolution. |
| Databáze: | OpenAIRE |
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