The Predictive Value of Proportional Evaluation Based on the Metabolic Activity of Cervical Lymph Nodes on PET/CT Imaging in Patients with Larynx Cancer
| Autor: | Osman Güven, Yavuz Uyar, Yavuz Atar, Savas Karyagar, Sevda Sağlampınar Karyağar, Onur Üstün |
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| Rok vydání: | 2020 |
| Předmět: |
lcsh:Medical physics. Medical radiology. Nuclear medicine
lcsh:R895-920 medicine.medical_treatment lcsh:Medicine positron emission tomography/computed tomography Standardized uptake value metabolic activity 030218 nuclear medicine & medical imaging Metastasis 03 medical and health sciences 0302 clinical medicine cervical lymph node Medicine Radiology Nuclear Medicine and imaging Lymph node lcsh:R5-920 medicine.diagnostic_test business.industry lcsh:R larynx cancer Neck dissection medicine.disease Primary tumor medicine.anatomical_structure Positron emission tomography Cervical lymph nodes 030220 oncology & carcinogenesis Original Article Lymph lcsh:Medicine (General) business Nuclear medicine |
| Zdroj: | Molecular Imaging and Radionuclide Therapy, Vol 29, Iss 2, Pp 59-64 (2020) Molecular Imaging and Radionuclide Therapy |
| ISSN: | 2147-1959 2146-1414 |
| DOI: | 10.4274/mirt.galenos.2019.92300 |
| Popis: | Objectives We aimed to evaluate the proportional values of maximum standardized uptake value (SUVmax) for cervical lymph nodes on 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for prediction of the presence of metastasis in patients with larynx squamous cell cancer (LSCC). Methods This retrospective study involved 43 patients with LSCC. All patients underwent resection of the primary tumor and neck dissection within 4 weeks after undergoing 18F-FDG PET/CT examinations. Receiver operating characteristic (ROC) analysis was performed to evaluate the lymph node SUVmax/primary tumor SUVmax (SUVmaxLN/SUVmaxPT), lymph node SUVmax/aortic SUVmax (SUVmaxLN/SUVmaxA), and lymph node SUVmax/ liver SUVmax (SUVmaxLN/SUVmaxL) ratios for diagnosis of lymph node metastasis. Results SUVmaxLN/SUVmaxA, SUVmaxLN/SUVmaxL, and SUVmaxLN/SUVmaxPT rates were significantly higher in metastatic lymph nodes compared to non-metastatic nodes. ROC analysis for metastasis showed that the cut-off thresholds were 3.87 for SUVmaxLN; 1.78 for SUVmaxLN /SUVmaxA; 1.08 for SUVmaxLN/SUVmaxL; and 0.36 for SUVmaxLN/SUVmaxPT. The diagnostic sensitivity, specificity and AUC were 83.7%, 77%, 0.856 for SUVmaxLN; 79.7%, 84%, 1.78 for SUVmaxLN/SUVmaxA; 84.1%, 76%, 0.833 for SUVmaxLN/SUVmaxL; and 53.6%, 76%, 0.666 for SUVmaxLN/SUVmaxPT, respectively. Conclusion SUVmaxLN/SUVmaxA, SUVmaxLN/SUVmaxL, and SUVmaxLN/SUVmaxPT ratios can be safely used for diagnosis of cervical lymph node metastasis in patients with LSCC. |
| Databáze: | OpenAIRE |
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