Effect of Cigarette Smoke Exposure on Maturation of the Antibody Response in Spleens of Newborn Mice

Autor:	Ruth B Cooper, Herbert B. Herscowitz
Rok vydání:	1979
Předmět:	Mice Inbred BALB C Erythrocytes Sheep business.industry Cigarette smoke exposure Antibodies Mice Plants Toxic Antibody response Animals Newborn Smoke Tobacco Pediatrics Perinatology and Child Health Immunology Animals Medicine Immunization Antigens Antibody-Producing Cells business Spleen
Zdroj:	Pediatric Research. 13:987-991
ISSN:	1530-0447 0031-3998
DOI:	10.1203/00006450-197909000-00007
Popis:	Balb/c mice were exposed to smoke from Kentucky Reference IRI cigarettes within 24 hr after birth on a Prototype Mark II Walton Horizontal Smoke Exposure Machine for various periods of time up to 10 wk of age. There was no difference in the magnitude of the splenic plaque-forming cells (PFC) response in smoke-exposed and untreated control animals immunized with sheep red blood cells (SRBC) on sequential days up to day 9 postpartum. However, beginning at day 10 and for each subsequent time period assayed thereafter, there was a statistically significant reduction in the number of splenic PFC observed in the smoke-exposed animals. On day 10, the PFC response of smoke-exposed mice was reduced by 33%, on day 14, there was a 60% reduction, whereas animals exposed to smoke from 4-10 wk showed a 90% reduction of the splenic PFC response.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e93f3dbef4b610aacb7a7c88f4569cfe https://doi.org/10.1203/00006450-197909000-00007 Zobrazit plný text záznamu