Low-grade inflammation in first-episode psychosis is determined by increased waist circumference

Autor: Tuula Kieseppä, Teemu Mäntylä, Maija Lindgren, Jaakko Reinikainen, Minna Torniainen-Holm, Eva Rikandi, Jouko Sundvall, Jaana Suvisaari, Jaakko Keinanen, Outi Mantere
Přispěvatelé: Department of Psychiatry, Clinicum, University of Helsinki, Nuorisopsykiatria, Children's Hospital, HUS Children and Adolescents, HUS Psychiatry
Rok vydání: 2018
Předmět:
Male
3124 Neurology and psychiatry
0302 clinical medicine
SCHIZOPHRENIA
Abdominal obesity
GENERAL-POPULATION
education.field_of_study
Anthropometry
biology
ATYPICAL ANTIPSYCHOTICS
BIPOLAR DISORDER
Chronic inflammation
Fasting
Middle Aged
DEPRESSION
Lipids
WEIGHT-GAIN
3. Good health
Psychiatry and Mental health
ADIPOSE-TISSUE
C-Reactive Protein
OBESITY
Obesity
Abdominal
Female
Waist Circumference
medicine.symptom
Adult
medicine.medical_specialty
Waist
Population
03 medical and health sciences
Sex Factors
Insulin resistance
Internal medicine
medicine
Humans
Risk factor
education
Weight gain
Triglycerides
Biological Psychiatry
Inflammation
business.industry
Cholesterol
HDL
C-reactive protein
Cholesterol
LDL
Cardiovascular risk
medicine.disease
Obesity
030227 psychiatry
PHYSICAL-ACTIVITY
Endocrinology
Psychotic Disorders
Early psychosis
biology.protein
Insulin Resistance
business
030217 neurology & neurosurgery
Zdroj: Psychiatry Research. 270:547-553
ISSN: 0165-1781
Popis: Psychosis is associated with low-grade inflammation as measured by high-sensitivity C-reactive protein (hs-CRP), a risk factor for cardiovascular events and mortality in the general population. We investigated the relationship between hs-CRP and anthropometric and metabolic changes in first-episode psychosis (FEP) during the first treatment year. We recruited 95 FEP patients and 62 controls, and measured longitudinal changes in hs-CRP, weight, waist circumference, insulin resistance, and lipids. We used linear mixed models to analyze the longitudinal relationship between hs-CRP and clinical, anthropometric and metabolic measures. At baseline, patients with FEP had higher levels of insulin resistance, total and low-density lipoprotein cholesterol, apolipoprotein B, and triglycerides. Baseline weight, waist circumference, hs-CRP, fasting glucose, and high-density lipoprotein cholesterol were similar between patients and controls. Marked increases in anthropometric measures and hs-CRP were observed in FEP during the 12-month follow-up. However, glucose and lipid parameters did not change significantly. In the mixed models, waist circumference and female sex were significant predictors of hs-CRP levels in FEP. Prevention of the early development of abdominal obesity in FEP is crucial, as abdominal obesity is accompanied by chronic low-grade inflammation, which increases further the cardiovascular risk in this vulnerable population.
Databáze: OpenAIRE
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