Low-grade inflammation in first-episode psychosis is determined by increased waist circumference
Autor: | Tuula Kieseppä, Teemu Mäntylä, Maija Lindgren, Jaakko Reinikainen, Minna Torniainen-Holm, Eva Rikandi, Jouko Sundvall, Jaana Suvisaari, Jaakko Keinanen, Outi Mantere |
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Přispěvatelé: | Department of Psychiatry, Clinicum, University of Helsinki, Nuorisopsykiatria, Children's Hospital, HUS Children and Adolescents, HUS Psychiatry |
Rok vydání: | 2018 |
Předmět: |
Male
3124 Neurology and psychiatry 0302 clinical medicine SCHIZOPHRENIA Abdominal obesity GENERAL-POPULATION education.field_of_study Anthropometry biology ATYPICAL ANTIPSYCHOTICS BIPOLAR DISORDER Chronic inflammation Fasting Middle Aged DEPRESSION Lipids WEIGHT-GAIN 3. Good health Psychiatry and Mental health ADIPOSE-TISSUE C-Reactive Protein OBESITY Obesity Abdominal Female Waist Circumference medicine.symptom Adult medicine.medical_specialty Waist Population 03 medical and health sciences Sex Factors Insulin resistance Internal medicine medicine Humans Risk factor education Weight gain Triglycerides Biological Psychiatry Inflammation business.industry Cholesterol HDL C-reactive protein Cholesterol LDL Cardiovascular risk medicine.disease Obesity 030227 psychiatry PHYSICAL-ACTIVITY Endocrinology Psychotic Disorders Early psychosis biology.protein Insulin Resistance business 030217 neurology & neurosurgery |
Zdroj: | Psychiatry Research. 270:547-553 |
ISSN: | 0165-1781 |
Popis: | Psychosis is associated with low-grade inflammation as measured by high-sensitivity C-reactive protein (hs-CRP), a risk factor for cardiovascular events and mortality in the general population. We investigated the relationship between hs-CRP and anthropometric and metabolic changes in first-episode psychosis (FEP) during the first treatment year. We recruited 95 FEP patients and 62 controls, and measured longitudinal changes in hs-CRP, weight, waist circumference, insulin resistance, and lipids. We used linear mixed models to analyze the longitudinal relationship between hs-CRP and clinical, anthropometric and metabolic measures. At baseline, patients with FEP had higher levels of insulin resistance, total and low-density lipoprotein cholesterol, apolipoprotein B, and triglycerides. Baseline weight, waist circumference, hs-CRP, fasting glucose, and high-density lipoprotein cholesterol were similar between patients and controls. Marked increases in anthropometric measures and hs-CRP were observed in FEP during the 12-month follow-up. However, glucose and lipid parameters did not change significantly. In the mixed models, waist circumference and female sex were significant predictors of hs-CRP levels in FEP. Prevention of the early development of abdominal obesity in FEP is crucial, as abdominal obesity is accompanied by chronic low-grade inflammation, which increases further the cardiovascular risk in this vulnerable population. |
Databáze: | OpenAIRE |
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