RNAIII-Inhibiting-Peptide-Loaded Polymethylmethacrylate Prevents In Vivo Staphylococcus aureus Biofilm Formation

Autor:	Marina Tuzova, Fiorenza Orlando, Robin Patel, Paloma Anguita-Alonso, Andrea Giacometti, Naomi Balaban, Oscar Cirioni, Vittorio Saba, Roberto Ghiselli, Giorgio Scalise, Milica Sevo
Rok vydání:	2007
Předmět:	Male Staphylococcus aureus endocrine system Micrococcaceae endocrine system diseases medicine.drug_class Antibiotics Peptide Staphylococcal infections medicine.disease_cause Microbiology Polymethacrylic Acids Vancomycin In vivo medicine Animals Experimental Therapeutics Pharmacology (medical) Rats Wistar Pharmacology chemistry.chemical_classification Drug Carriers Dose-Response Relationship Drug biology Biofilm Staphylococcal Infections biology.organism_classification medicine.disease Microspheres Anti-Bacterial Agents Rats Disease Models Animal Infectious Diseases chemistry Biofilms Oligopeptides medicine.drug
Zdroj:	Antimicrobial Agents and Chemotherapy. 51:2594-2596
ISSN:	1098-6596 0066-4804
DOI:	10.1128/aac.00580-06
Popis:	Staphylococci, common orthopedic pathogens, form antibiotic-resistant biofilms. Polymethylmethacrylate (PMMA) beads loaded with the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP) were implanted in rats and shown to prevent methicillin-resistant Staphylococcus aureus infection. RIP release was bimodal, typical of previously-tested antibiotics. These results suggest that RIP-PMMA warrants further evaluation for management of orthopedic infections caused by staphylococci.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e93caf1a1c7d63a3938e7f4bccd070de https://doi.org/10.1128/aac.00580-06 Zobrazit plný text záznamu