Antiretroviral Therapy Initiation Alters the Redox System of Asymptomatic HIV-Infected Individuals: A Longitudinal Study

Autor: Francilene Capel Tavares, Camila Renata Corrêa, Mariana Gatto, Caio Cavassan de Camargo, Mara Biasin, Karen Ingrid Tasca, Alexandrina Sartori, Lenice do Rosário de Souza, Juliana Trindade Caleffi
Přispěvatelé: Universidade Estadual Paulista (Unesp), University of Milan
Rok vydání: 2016
Předmět:
0301 basic medicine
CD4-Positive T-Lymphocytes
Male
Aging
Longitudinal study
alpha-Tocopherol
Physiology
HIV Infections
medicine.disease_cause
Dinoprost
Biochemistry
Antioxidants
chemistry.chemical_compound
0302 clinical medicine
Malondialdehyde
Medicine
Longitudinal Studies
Chromatography
High Pressure Liquid
lcsh:Cytology
General Medicine
Middle Aged
medicine.anatomical_structure
Anti-Retroviral Agents
030220 oncology & carcinogenesis
Reverse Transcriptase Inhibitors
Drug Therapy
Combination
Female
medicine.symptom
Oxidation-Reduction
Research Article
Cart
Adult
medicine.medical_specialty
Article Subject
DNA damage
T cell
Enzyme-Linked Immunosorbent Assay
Asymptomatic
03 medical and health sciences
Young Adult
Pharmacotherapy
Humans
lcsh:QH573-671
business.industry
Cell Biology
Surgery
CD4 Lymphocyte Count
030104 developmental biology
chemistry
business
Oxidative stress
DNA Damage
Zdroj: Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2017 (2017)
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
ISSN: 1942-0994
Popis: Made available in DSpace on 2018-12-11T17:11:08Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-01-01 Background. The combination antiretroviral therapy (cART) increases the oxidative stress in HIV-infected people, which in turn favors the onset and aggravation of non-AIDS comorbidities, a common situation affecting these individuals. We aimed to evaluate the influence of cART initiation on oxidative stress parameters. This is a longitudinal study including 30 asymptomatic patients divided according to their CD4+ T cell count (G1: 500 cell/mL) before (M0) and after (M1) cART initiation. We analyzed total antioxidant capacity (TAC), fat-soluble vitamins, malondialdehyde, 8-isoprostane, and DNA damage. Results. Results showed a decrease in TAC, retinol, α-tocopherol, and some carotenoids, in addition to a significant increase in DNA damage at M1. These changes were more evident in G2 subjects. Moreover, there was a significant 8-isoprostane increase at M1 in individuals belonging to G1. Conclusion. The results indicate that cART interfered in the redox system, mainly by reducing the antioxidant defenses. In addition, patients who had CD4+ T counts higher than 500 cells/mm3 showed more susceptibility to genotoxicity, while patients with less CD4+ T counts displayed more damage triggered by lipoperoxidation. Considering the early beginning of cART, its chronic use, and its capacity to alter the redox status, further long-term studies on larger cohorts are needed to define the best time to initiate therapy and to investigate new strategies to delay the development of non-AIDS diseases. Department of Tropical Diseases Botucatu Medical School (FMB) Universidade Estadual Paulista (UNESP) Department of Pathology FMB UNESP Department of Biomedical and Clinical Sciences University of Milan Department of Tropical Diseases Botucatu Medical School (FMB) Universidade Estadual Paulista (UNESP) Department of Pathology FMB UNESP
Databáze: OpenAIRE
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