Regression of sporadic intra-abdominal desmoid tumour following administration of non-steroidal anti-inflammatory drug
| Autor: | Tohru Tsujimura, Naohiro Tomita, Keita Tanaka, Makoto Gega, Yoshinori Fujiwara, Reigetsu Yoshikawa, Syozo Hirota, Tomoko Hashimoto-Tamaoki, Hidenori Yanagi |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Pathology lcsh:Surgery CD34 Case Report Fibromatosis Abdominal lcsh:RC254-282 Familial adenomatous polyposis Prostate cancer Surgical oncology Biopsy medicine Humans Abdominal Neoplasms Aged medicine.diagnostic_test business.industry Anti-Inflammatory Agents Non-Steroidal Fibromatosis lcsh:RD1-811 lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease body regions Bowel obstruction Fibromatosis Aggressive Treatment Outcome Oncology Surgery Radiology Tomography X-Ray Computed business |
| Zdroj: | World Journal of Surgical Oncology World Journal of Surgical Oncology, Vol 6, Iss 1, p 17 (2008) |
| ISSN: | 1477-7819 |
| DOI: | 10.1186/1477-7819-6-17 |
| Popis: | Background Desmoid tumours or fibromatoses are rare entities characterized by the benign proliferation of fibroblasts, which can be life-threatening due to their locally aggressive properties. Surgery is widely accepted as the first line of treatment for extra-abdominal desmoids; however, it is not recommended for intra-abdominal desmoids because of the high-risk of recurrence and difficulties with the operation. Here, we report on a patient with sporadic intra-abdominal desmoid tumours, who showed partial response following the intake of non-steroidal anti-inflammatory drugs. Case presentation A 73-year-old man presented with swelling and pain of the right leg. Computed tomography showed an abnormal multilocular soft-tissue mass (95 × 70 mm) in the right pelvis, which was revealed by biopsy to be a desmoid tumour. Immunohistochemical analysis showed that the tumour cells expressed vimentin, but not smooth-muscle actin, CD34, or desmin. Very few Ki-67-positive cells were found. Non-cytotoxic treatment with etodolac (200 mg/day) was chosen because of the patient's age, lack of bowel obstruction, and the likelihood of prostate cancer. Two years after the commencement of non-steroidal anti-inflammatory drug administration, computed tomography showed a decrease in tumour size (63 × 49 mm), and the disappearance of intratumoural septa. Conclusion Our case report suggests that non-steroidal anti-inflammatory drug treatment should be taken into consideration for use as first-line treatment in patients with sporadic intra-abdominal desmoid tumours. |
| Databáze: | OpenAIRE |
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