Association of glutathione S-transferase P1 gene polymorphism with the risk of small-cell carcinoma of lung cancer
| Autor: | Pei-Zhang Li, Ming Lao, Hui-Liu Zhao, Bo Zhu, Chao Ou, Le-Qun Li, Ling-Sha Huang |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Oncology
medicine.medical_specialty Turkish population Genotype Biology Biochemistry Small-cell carcinoma Polymorphism Single Nucleotide GSTP1 Asian People Risk Factors Internal medicine medicine Carcinoma Humans Genetic Predisposition to Disease Allele Lung cancer Molecular Biology Alleles Genetic Association Studies Cell Biology medicine.disease Small Cell Lung Carcinoma Glutathione S-Transferase pi Cancer research Gene polymorphism |
| Zdroj: | Journal of receptor and signal transduction research. 35(2) |
| ISSN: | 1532-4281 |
| Popis: | The conclusions of the published reports on the relationship between glutathione S-transferase P1 (GSTP1) gene polymorphism and the risk of small-cell carcinoma of lung cancer are still debated. GSTP1 is one of the important mutant sites reported at present. This meta-analysis was performed to evaluate the association between GSTP1 and the risk of small-cell carcinoma of lung cancer. The association investigations were identified from PubMed and Cochrane Library, and eligible studies were included and synthesized using meta-analysis method. Ten reports were included into this meta-analysis for the association of GSTP1 A/G gene polymorphism and small-cell carcinoma of lung cancer. The G allele and GG genotype were not associated with the susceptibility of risk of small-cell carcinoma in overall populations, East-Asians and Turkish population. However, there was an association between GG genotype with the risk of small-cell carcinoma in Caucasians. In conclusion, GG genotype was associated with the risk of small-cell carcinoma in Caucasian patients with lung cancer. However, GSTP1 A/G gene polymorphism is not associated with the susceptibility of small-cell carcinoma in overall populations, East-Asians and Turkish population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|