Reduced infiltration of regulatory T cells in tumours from mice fed daily with gamma-tocotrienol supplementation
| Autor: | Mei Han Ng, Kanga Rani Selvaduray, Premdass Ramdas, Ammu Kutty Radhakrishnan, Shonia Subramaniam, Methil Kannan Kutty, Jeya Seela Anandha Rao |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_treatment
Immunology Mammary Neoplasms Animal Biology T-Lymphocytes Regulatory Andrology Mice Immune system Lymphocytes Tumor-Infiltrating Interferon Cell Line Tumor medicine Tumor Microenvironment Immunology and Allergy Animals Mice Inbred BALB C gamma-Tocopherol Interleukin FOXP3 Acquired immune system Neoplasm Proteins Killer Cells Natural Cytokine Cancer cell Dietary Supplements Cytokines Female ORIGINAL ARTICLES CD8 medicine.drug |
| Zdroj: | Clin Exp Immunol |
| ISSN: | 1365-2249 |
| Popis: | Gamma-tocotrienol (γT3) is an analogue of vitamin E with beneficial effects on the immune system, including immune-modulatory properties. This study reports the immune-modulatory effects of daily supplementation of γT3 on host T helper (Th) and T regulatory cell (Treg) populations in a syngeneic mouse model of breast cancer. Female BALB/c mice were fed with either γT3 or vehicle (soy oil) for 2 weeks via oral gavage before they were inoculated with syngeneic 4T1 mouse mammary cancer cells (4T1 cells). Supplementation continued until the mice were euthanized. Mice (n = 6) were euthanized at specified time-points for various analysis (blood leucocyte, cytokine production and immunohistochemistry). Tumour volume was measured once every 7 days. Gene expression studies were carried out on tumour-specific T lymphocytes isolated from splenic cultures. Supplementation with γT3 increased CD4+ (p |
| Databáze: | OpenAIRE |
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