Thyroid dysfunction in COVID-19
| Autor: | Kunal Kumar, Aashima Dabas, Urmila Jhamb, Binita Goswami, Sangeeta Yadav, Sandeep Garg, Harpreet Singh, Abhishek Dubey |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19) Endocrinology Diabetes and Metabolism RC799-869 Thyroid function tests Gastroenterology Thyroiditis Diseases of the endocrine glands. Clinical endocrinology Endocrinology Disease severity Thyroid dysfunction Internal medicine il-6 medicine Euthyroid medicine.diagnostic_test business.industry Thyroid disease Odds ratio Diseases of the digestive system. Gastroenterology medicine.disease RC648-665 inflammatory marker sick euthyroid thyroiditis Original Article hypothyroidism business |
| Zdroj: | Indian Journal of Endocrinology and Metabolism, Vol 25, Iss 3, Pp 198-201 (2021) Indian Journal of Endocrinology and Metabolism |
| ISSN: | 2230-8210 |
| Popis: | Objective: The aim of this study was to evaluate thyroid dysfunction in COVID-19 and study its association with disease severity in COVID-19. Methods: Patients with confirmed COVID-19 infection who were admitted to dedicated COVID hospital were recruited over 3 months period. Those with pre-existing thyroid disease were excluded. The thyroid function tests were performed and correlated with interleukin-6 levels. Results: A total of 164 patients (14 children) with mean(SD) age 53.85 (19.54) years were recruited. The proportion of patients with mild, moderate and severe disease were 22 (13.4%), 78 (47.6%) and 64 (39.0%), respectively, among which 12 (54.5%), 56 (71.8%) and 43 (67.2%) patients had thyroid dysfunction, respectively; P = 0.309. Eighty eight (53.7%) had sick euthyroid (84 had low fT3 only), 14 had overt hypothyroidism and 9 had thyroiditis. Median (IQR) levels of serum fT3 showed significant decline from mild category [4.54 (3.81, 5.27)], to moderate [3.95 (3.67, 4.24)] and severe category [3.56 (3.22, 3.89)]; P = 0.011. Low fT3 had significant risk [odds ratio (95% CI)] of death [2.634 (1.01, 6.87); P = 0.031] and elevated IL-6 [2.575 (1.084, 6.118); P = 0.021]. Conclusion: Sick euthyroid was seen in the majority of patients hospitalized with COVID. Low fT3 was associated with death and increased inflammation, suggesting poor prognosis. |
| Databáze: | OpenAIRE |
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