Genetic Contributions to The Association Between Adult Height and Head and Neck Cancer: A Mendelian Randomization Analysis

Autor: Luigi Barzan, Vladimir Janout, Anna Puggina, Kristina Kjærheim, James McKay, Valerie Gaborieau, Paul Brennan, Pagona Lagiou, Jolanta Lissowska, Antonio Agudo, Cristina Canova, Ioan Nicolae Mates, David I. Conway, Ivana Holcatova, Xavier Castellsagué, Lorenzo Richiardi, Eleonora Fabianova, Ariana Znaor, Vladimir Bencko, Lenka Foretova, Nalin Thakker, Wolfgang Ahrens, Neonilia Szeszenia-Dabrowska, Stefania Boccia, Tatiana V. Macfarlane, Claire M. Healy, Roberta Pastorino, David Zaridze, Robert Carreras-Torres
Přispěvatelé: Nofer Institute of Occupational Medicine
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Oncology
Male
lcsh:Medicine
0302 clinical medicine
risk factors
lcsh:Science
Multidisciplinary
Confounding
Mendelian Randomization Analysis
Middle Aged
3. Good health
Creixement humà
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Female
cancer epidemiology
medicine.medical_specialty
Single-nucleotide polymorphism
Cancer epidemiology
Risk factors
Human growth
Polymorphism
Single Nucleotide
Article
POOLED ANALYSIS
EPIDEMIOLOGY CONSORTIUM
03 medical and health sciences
Internal medicine
Mendelian randomization
medicine
Genetic predisposition
Genetics
Humans
Genetic Predisposition to Disease
Settore MED/42 - IGIENE GENERALE E APPLICATA
Genetic association
Aged
business.industry
lcsh:R
Odds ratio
Neck cancer
Confidence interval
Body Height
Càncer de coll
030104 developmental biology
PROSPECTIVE COHORT
Case-Control Studies
RISK-FACTORS
lcsh:Q
business
Genètica
Genome-Wide Association Study
Zdroj: Scientific Reports, Vol 8, Iss 1, Pp 1-6 (2018)
Recercat. Dipósit de la Recerca de Catalunya
instname
Pastorino, R, Puggina, A, Carreras-Torres, R, Lagiou, P, Holcátová, I, Richiardi, L, Kjaerheim, K, Agudo, A, Castellsagué, X, Macfarlane, T V, Barzan, L, Canova, C, Thakker, N S, Conway, D I, Znaor, A, Healy, C M, Ahrens, W, Zaridze, D, Szeszenia-Dabrowska, N, Lissowska, J, Fabianova, E, Mates, I N, Bencko, V, Foretova, L, Janout, V, Brennan, P, Gaborieau, V, McKay, J D & Boccia, S 2018, ' Genetic Contributions to the Association between Adult Height and Head and Neck Cancer : A Mendelian Randomization Analysis ', Scientific Reports, vol. 8, no. 1, 4534 . https://doi.org/10.1038/s41598-018-22626-w
Scientific Reports
Scientific reports, 8: 4534
Dipòsit Digital de la UB
Universidad de Barcelona
ISSN: 2045-2322
Popis: With the aim to dissect the effect of adult height on head and neck cancer (HNC), we use the Mendelian randomization (MR) approach to test the association between genetic instruments for height and the risk of HNC. 599 single nucleotide polymorphisms (SNPs) were identified as genetic instruments for height, accounting for 16% of the phenotypic variation. Genetic data concerning HNC cases and controls were obtained from a genome-wide association study. Summary statistics for genetic association were used in complementary MR approaches: the weighted genetic risk score (GRS) and the inverse-variance weighted (IVW). MR-Egger regression was used for sensitivity analysis and pleiotropy evaluation. From the GRS analysis, one standard deviation (SD) higher height (6.9 cm; due to genetic predisposition across 599 SNPs) raised the risk for HNC (Odds ratio (OR), 1.14; 95% Confidence Interval (95%CI), 0.99–1.32). The association analyses with potential confounders revealed that the GRS was associated with tobacco smoking (OR = 0.80, 95% CI (0.69–0.93)). MR-Egger regression did not provide evidence of overall directional pleiotropy. Our study indicates that height is potentially associated with HNC risk. However, the reported risk could be underestimated since, at the genetic level, height emerged to be inversely associated with smoking.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje