Mechanisms and Practical Use of Biologic Therapies for Allergy and Asthma Indications
| Autor: | Cecelia Damask, Christine B. Franzese |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Allergy
medicine.drug_class business.industry Biologic therapies Antibodies Monoclonal General Medicine medicine.disease Bioinformatics Monoclonal antibody Rhinitis Allergic Asthma Proinflammatory cytokine Biological Therapy 03 medical and health sciences 0302 clinical medicine Otorhinolaryngology Underlying disease Novel agents 030220 oncology & carcinogenesis medicine Humans 030223 otorhinolaryngology business Anti il 13 |
| Zdroj: | Otolaryngologic clinics of North America. 54(4) |
| ISSN: | 1557-8259 |
| Popis: | This article presents a concise overview of the important aspects of the immunologic mechanisms targeted by T-helper 2-directed monoclonal antibodies, as well as their practical applications in the treatment of allergic disorders (specifically allergic rhinitis) and asthma. Several of these novel agents treat multiple diseases, so understanding their targets and the underlying disease process can aid patient selection. In addition, the particular targets of the therapeutics seem to be shifting to include not only agents that intervene against inflammatory cytokines or their receptors but also specific molecular epitopes and cellular surface proteins. |
| Databáze: | OpenAIRE |
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