Designing helical peptide inhibitors of protein-protein interactions
| Autor: | Amy E. Keating, Raheleh Rezaei Araghi |
|---|---|
| Přispěvatelé: | Massachusetts Institute of Technology. Department of Biological Engineering, Massachusetts Institute of Technology. Department of Biology, Rezaei Araghi, Raheleh, Keating, Amy E. |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Protein Conformation alpha-Helical MDMX Peptidomimetic medicine.medical_treatment Protein design Peptide Biology Gp41 Article Protein–protein interaction 03 medical and health sciences Structural Biology medicine Animals Humans Molecular Biology chemistry.chemical_classification Protease Proteins Small molecule 030104 developmental biology Biochemistry chemistry Drug Design Peptides Protein Binding |
| Zdroj: | PMC |
| Popis: | Short helical peptides combine characteristics of small molecules and large proteins and provide an exciting area of opportunity in protein design. A growing number of studies report novel helical peptide inhibitors of protein-protein interactions. New techniques have been developed for peptide design and for chemically stabilizing peptides in a helical conformation, which frequently improves protease resistance and cell permeability. We summarize advances in peptide crosslinking chemistry and give examples of peptide design studies targeting coiled-coil transcription factors, Bcl-2 family proteins, MDM2/MDMX, and HIV gp41, among other targets. National Institute of General Medical Sciences (U.S.) (Award GM067681) National Institute of General Medical Sciences (U.S.) (Award GM110048) National Institute of General Medical Sciences (U.S.) (Award GM084181) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|