Oral vancomycin treatment does not alter markers of postprandial inflammation in lean and obese subjects

Autor: Nicolien C. de Clercq, Guido J. Bakker, Daniël H. van Raalte, Maaike Winkelmeijer, Hilde Herrema, Jeffrey Kroon, E. M. Kemper, Emma C. E. Meessen, Johan G. Schnitzler, Annefleur M. Koopen, Maarten R. Soeters, Torsten P. M. Scheithauer, Siroon Bekkering, Patrice D. Cani, Annick V. Hartstra, Geesje M. Dallinga-Thie, Albert K. Groen, Max Nieuwdorp
Přispěvatelé: UCL - SSS/LDRI - Louvain Drug Research Institute, Graduate School, Vascular Medicine, ACS - Atherosclerosis & ischemic syndromes, ACS - Diabetes & metabolism, AGEM - Digestive immunity, AGEM - Endocrinology, metabolism and nutrition, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Adult Psychiatry, Pharmacy, Endocrinology, Experimental Vascular Medicine, ACS - Microcirculation, AII - Inflammatory diseases, 01 Internal and external specialisms, Center for Liver, Digestive and Metabolic Diseases (CLDM), Lifestyle Medicine (LM)
Rok vydání: 2019
Předmět:
Lipopolysaccharides
Male
SYSTEMIC INFLAMMATION
CIRCULATING MONOCYTES
obesity
Physiology
lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]
030204 cardiovascular system & hematology
Gut flora
Systemic inflammation
lcsh:Physiology
Monocytes
0302 clinical medicine
Original Research
Body surface area
Metabolic Syndrome
Meal
biology
lcsh:QP1-981
GUT MICROBIOTA
AUGMENTS MONOCYTE RESPONSES
Middle Aged
Postprandial Period
INHIBITORY-ACTIVITY
Anti-Bacterial Agents
Postprandial
LIPOPOLYSACCHARIDE-BINDING PROTEIN
Endocrine and Metabolic Conditons
Disorders and Treatments
medicine.symptom
Lipopolysaccharide binding protein
Adipose Tissue and Obesity
Adult
medicine.medical_specialty
LPS
Immunology
Inflammation
03 medical and health sciences
All institutes and research themes of the Radboud University Medical Center
Vancomycin
Physiology (medical)
Internal medicine
medicine
ENDOTOXEMIA
Humans
bacterial translocation
Obesity
business.industry
Bacterial endotoxins
biology.organism_classification
medicine.disease
Dietary Fats
Gastrointestinal Microbiome
SEVERE SEPSIS
Endocrinology
Bacterial translocation
FAT
biology.protein
Metabolic syndrome
business
030217 neurology & neurosurgery
Zdroj: Physiological Reports
Physiological reports, Vol. 7, no.16, p. e14199 [1-13] (2019)
Physiological Reports, Vol 7, Iss 16, Pp n/a-n/a (2019)
Physiological Reports, 7, 16
Physiological Reports, 7
Physiological reports, 7(16):e14199. John Wiley and Sons Inc.
Physiological Reports, 7(16):14199. Wiley
ISSN: 2051-817X
Popis: Intake of a high‐fat meal induces a systemic inflammatory response in the postprandial which is augmented in obese subjects. However, the underlying mechanisms of this response have not been fully elucidated. We aimed to assess the effect of gut microbiota modulation on postprandial inflammatory response in lean and obese subjects. Ten lean and ten obese subjects with metabolic syndrome received oral vancomycin 500 mg four times per day for 7 days. Oral high‐fat meal tests (50 g fat/m2 body surface area) were performed before and after vancomycin intervention. Gut microbiota composition, leukocyte counts, plasma lipopolysaccharides (LPS), LPS‐binding protein (LBP), IL‐6 and MCP‐1 concentrations and monocyte CCR2 and cytokine expression were determined before and after the high‐fat meal. Oral vancomycin treatment resulted in profound changes in gut microbiota composition and significantly decreased bacterial diversity in both groups (phylogenetic diversity pre‐ versus post‐intervention: lean, 56.9 ± 7.8 vs. 21.4 ± 6.6, P
Databáze: OpenAIRE
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