Effect of Anthrax Immune Globulin on Response to BioThrax (Anthrax Vaccine Adsorbed) in New Zealand White Rabbits
| Autor: | Nina V. Malkevich, Mario H. Skiadopoulos, Gary S. Nabors, Boris Ionin, Kristin H. Clement, Ronald T. Aimes, Ajoy C. Chakrabarti, Subhendu Basu, Thomas L. Rudge |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Anthrax Vaccines Biology complex mixtures Anthrax Antigen Animals Humans Pharmacology (medical) Experimental Therapeutics Infusions Intravenous Respiratory Tract Infections Pharmacology Anthrax vaccines Anthrax immune globulin fungi Vaccination Anthrax Vaccine Adsorbed Immunoglobulins Intravenous biology.organism_classification bacterial infections and mycoses Virology Antibodies Bacterial Bacillus anthracis Infectious Diseases Immunization Area Under Curve Immunology biology.protein Female Rabbits Antibody Drug Antagonism Half-Life |
| Popis: | Development of anthrax countermeasures that may be used concomitantly in a postexposure setting requires an understanding of the interaction between these products. Anthrax immune globulin intravenous (AIGIV) is a candidate immunotherapeutic that contains neutralizing antibodies against protective antigen (PA), a component of anthrax toxins. We evaluated the interaction between AIGIV and BioThrax (anthrax vaccine adsorbed) in rabbits. While pharmacokinetics of AIGIV were not altered by vaccination, the vaccine-induced immune response was abrogated in AIGIV-treated animals. |
| Databáze: | OpenAIRE |
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