Hybrid NMR: A Union of Solution- and Solid-State NMR
| Autor: | Adrian W. Draney, Justin L. Lorieau, Pallavi Thiagarajan-Rosenkranz |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Electron density
Aqueous solution Carbon-13 NMR satellite Analytical chemistry 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Biochemistry Catalysis Spectral line 0104 chemical sciences chemistry.chemical_compound Colloid and Surface Chemistry Solid-state nuclear magnetic resonance chemistry Chemical physics Tensor Carboxylate 0210 nano-technology Anisotropy |
| Zdroj: | Journal of the American Chemical Society. 139(13) |
| ISSN: | 1520-5126 |
| Popis: | Hybrid NMR (hdNMR) is a powerful new tool that combines the strengths of solution- and solid-state NMR to measure dipolar, chemical shift, and quadrupolar tensors in aqueous solution. We introduce the theory of hdNMR and partially randomly oriented (PRO) crystalline hydrogel samples. PRO samples produce randomly oriented spectra with characteristic Pake patterns from the solid state, yet they maintain the high-resolution dispersion of solution NMR experiments. With new pulse sequences, we show how hdNMR can be used to measure with high precision the 1Hα–13Cα dipolar tensor and carboxylate chemical shift anisotropy tensor of aspartate. These measurements contain detailed information on the distribution of electron density, interatomic distances, and the orientation dependence of molecular motion. |
| Databáze: | OpenAIRE |
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