Phase‐shift Perfluoropentane Nanoemulsions Enhance Pulsed High‐intensity Focused Ultrasound Ablation in an Isolated Perfused Liver System and Their Potential Value for Cancer Therapy
| Autor: | Xu Chao, Feng Wu, Jianzhong Zou, Guo-Guan Wang, Lu-Yan Zhao, Bing-She Yang |
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| Rok vydání: | 2021 |
| Předmět: |
Fluorocarbons
Necrosis Radiological and Ultrasound Technology business.industry medicine.medical_treatment Ultrasound Ablation High-intensity focused ultrasound PLGA chemistry.chemical_compound Liver chemistry Neoplasms Perfused liver medicine Animals High-Intensity Focused Ultrasound Ablation Radiology Nuclear Medicine and imaging Rabbits medicine.symptom business Nuclear medicine Ultrasound energy Saline |
| Zdroj: | Journal of Ultrasound in Medicine. 41:107-121 |
| ISSN: | 1550-9613 0278-4297 |
| Popis: | PURPOSE To investigate whether phase-shift perfluoropetane (PFP) nanoemulsions can enhance pulsed high-intensity focused ultrasound (HIFU) ablation. METHODS PFP was encapsulated by poly(lactic-co-glycolic acid) (PLGA) to form a nanometer-sized droplet (PLGA-PFP), which was added to an isolated perfused liver system. Meanwhile, phosphate-buffered saline (PBS) was used as a control. The perfused liver was exposed to HIFU (150 W, t = 3/5/10 s) at various duty cycles (DCs). The ultrasound images, cavitation emissions, and temperature were recorded. Rabbits with subcutaneous VX2 tumors were exposed to HIFU (150 W) at various DCs with or without PLGA-PFP. After ablation, necrosis volume and energy efficiency factor were calculated. Pathologic characteristics were observed. RESULTS Compared to the PBS control, PLGA-PFP nanoemulsions markedly enhanced HIFU-induced necrosis volume in both perfused livers and subcutaneous VX2 tumor-bearing rabbits (P |
| Databáze: | OpenAIRE |
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