Noninvasive functional imaging of human brain using light
| Autor: | Jens Frahm, Eben L. Kermit, David A. Benaron, David K. Stevenson, J. C. van Houten, Hellmuth Obrig, Andreas Kleinschmidt, Wai-Fung Cheong, Christina Hirth, David A. Boas, Arno Villringer, Susan R. Hintz |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Diagnostic Imaging Optics and Photonics Light Electroencephalography Motor Activity 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Nuclear magnetic resonance medicine Humans Hypoxia Photon diffusion Tomography Tomographic reconstruction medicine.diagnostic_test business.industry Infant Newborn Brain Magnetic resonance imaging Oxygenation Human brain Magnetic Resonance Imaging Functional imaging medicine.anatomical_structure Neurology sense organs Neurology (clinical) Cardiology and Cardiovascular Medicine Functional magnetic resonance imaging business Nuclear medicine Tomography X-Ray Computed 030217 neurology & neurosurgery |
| Zdroj: | Journal of Cerebral Blood Flow & Metabolism |
| ISSN: | 0271-678X |
| Popis: | Analysis of photon transit time for low-power light passing into the head, and through both skull and brain, of human subjects allowed for tomographic imaging of cerebral hemoglobin oxygenation based on photon diffusion theory. In healthy adults, imaging of changes in hemoglobin saturation during hand movement revealed focal, contralateral increases in motor cortex oxygenation with spatial agreement to activation maps determined by functional magnetic resonance imaging; in ill neonates, imaging of hemoglobin saturation revealed focal regions of low oxygenation after acute stroke, with spatial overlap to injury location determined by computed tomography scan. Because such slow optical changes occur over seconds and co-localize with magnetic resonance imaging vascular signals whereas fast activation-related optical changes occur over milliseconds and co-localize with EEG electrical signals, optical methods offer a single modality for exploring the spatio-temporal relationship between electrical and vascular responses in the brain in vivo, as well as for mapping cortical activation and oxygenation at the bedside in real-time for clinical monitoring. |
| Databáze: | OpenAIRE |
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