Synthesis of some steroid spin labels
| Autor: | J.R. Dodd, Abraham E. Mathew |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Hydrocortisone
Stereochemistry medicine.medical_treatment Clinical Biochemistry chemistry.chemical_element Biochemistry Steroid chemistry.chemical_compound Chromium Endocrinology medicine Testosterone Spin label Molecular Biology Transcortin Pharmacology Diketone Organic Chemistry Electron Spin Resonance Spectroscopy Nitroxyl Cortisone Dicyclohexylcarbodiimide chemistry Yield (chemistry) Spin Labels Enone medicine.drug |
| Zdroj: | Steroids. 42:241-247 |
| ISSN: | 0039-128X |
| DOI: | 10.1016/0039-128x(83)90036-3 |
| Popis: | An improved synthesis of spin-labeled cortisol, cortisone, and testosterone using N, N'-cyclohexylcarbodiimide (DCC) is reported. The spin labeled steroids are shown to result from the esterification at the most reactive C(21) and C(17) hydroxyl groups. A mild and high yield oxidation of cortisol spin label to cortisone spin label by chromium trioxide-pyridine is also discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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