Protective Effects of Simvastatin Against Alendronate-Induced Gastric Mucosal Injury in Rats
| Autor: | Nayara A. Sousa, Lucas A.D. Nicolau, Pedro Marcos Gomes Soares, Thiago S.L. Araújo, Jand Venes R. Medeiros, Luan Kelves Miranda de Souza, Renan O. Silva, Douglas S. Costa, Nathalia S. Carvalho, Mônica Moraes Silva |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Simvastatin Statin Physiology medicine.drug_class Interleukin-1beta Pharmacology medicine.disease_cause 03 medical and health sciences chemistry.chemical_compound Malondialdehyde medicine Gastric mucosa Animals Stomach Ulcer Rats Wistar Peroxidase Alendronate Bone Density Conservation Agents Dose-Response Relationship Drug biology Tumor Necrosis Factor-alpha business.industry Stomach Gastroenterology nutritional and metabolic diseases Glutathione Mucus Rats 030104 developmental biology medicine.anatomical_structure Gene Expression Regulation chemistry Gastric Mucosa Myeloperoxidase biology.protein Female Hydroxymethylglutaryl-CoA Reductase Inhibitors business Oxidative stress medicine.drug |
| Zdroj: | Digestive Diseases and Sciences. 61:400-409 |
| ISSN: | 1573-2568 0163-2116 |
| Popis: | It has been reported that simvastatin, a statin commonly prescribed for its anti-inflammatory and antioxidant effects, has gastroprotective effects in indomethacin and ethanol-induced gastric ulcers. However, the effects of simvastatin on alendronate-induced gastric mucosal injury remain unexplored. This study investigated the use of simvastatin for the treatment of alendronate-induced gastric ulcers in rats. Female rats were pretreated with vehicle or simvastatin (20 and 60 mg/kg p.o.). After 1 h, the rats received alendronate (50 mg/kg p.o.). Simvastatin was administered once daily for 7 days, and from the fourth day of simvastatin treatment, alendronate was administered once daily for 4 days. On the final day of treatment, 4 h after alendronate administration, animals were euthanized, their stomachs were removed, and gastric damage was measured. Samples of the stomach were fixed in 10 % formalin immediately after their removal for subsequent histopathological assessment. Unfixed samples were weighed, frozen at −80 °C until assayed for glutathione (GSH), malondialdehyde (MDA), and cytokine levels and myeloperoxidase (MPO) activity. A third group was used to measure mucus and gastric secretion. Pretreatment with simvastatin prevented alendronate-induced macroscopic gastric damage and reduced the levels of MDA and GSH, TNF-α and IL-1β, MPO activity, and mucus levels, in the stomach. This study demonstrates the protective effects of simvastatin against alendronate-induced gastric ulceration. Maintenance of mucosal integrity, inhibition of neutrophil activity, and reduced oxidative stress associated with decreased gastric acidity may explain the gastroprotective effects of simvastatin. |
| Databáze: | OpenAIRE |
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