Comparative effects of the polychlorinated biphenyl mixture, Aroclor 1242, on porphyrin and xenobiotic metabolism in kidney of Japanese quail and rat
| Autor: | H. S. Nakaue, Donald R. Buhler, Cristobal L. Miranda, Marilyn C. Henderson, Jun-Lan Wang |
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| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Aroclors Porphyrins Urinary system Immunology 7-Alkoxycoumarin O-Dealkylase Coturnix Biology Kidney Xenobiotics chemistry.chemical_compound Cytochrome P-450 Enzyme System Internal medicine biology.animal medicine Cytochrome P-450 CYP1A1 Animals Uroporphyrinogen Decarboxylase Rats Wistar Uroporphyrinogen decarboxylase activity Glutathione Transferase Pharmacology urogenital system Polychlorinated biphenyl Glutathione Metabolism Quail Rats medicine.anatomical_structure Endocrinology chemistry Oxidoreductases Drug metabolism 5-Aminolevulinate Synthetase |
| Zdroj: | Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology. 103(1) |
| ISSN: | 0742-8413 |
| Popis: | 1. Aroclor 1242 (500 mg/kg, p.o.) produced a marked increase in porphyrin content of quail kidney (1800-fold), and of rat kidney but to a lesser extent (6-fold). 2. δ-Aminolevulinic acid synthetase activity was increased 12-fold in quail kidney but was unchanged in rat kidney folowing Aroclor 1242 treatment. 3. Uroporphyrinogen decarboxylase activity was significantly inhibited in quail kidney but not in rat kidney. 4. Renal ethoxyresorufin O-deethylase activity was induced in rat and quail whereas renal ethoxycoumarin O-deethylase and glutathione S-transferase activities were induced only in rats by Aroclor 1242. |
| Databáze: | OpenAIRE |
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