Asthma and Farm Exposures in a Cohort of Rural Iowa Children
| Autor: | Peter S. Thorne, Wayne T. Sanderson, James A. Merchant, Allison L. Naleway, Erik R. Svendsen, Elizabeth A. Chrischilles, Craig Taylor, Leon F. Burmeister, Kevin M. Kelly, Ann M. Stromquist, Stephen J. Reynolds |
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| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Male
Rural Population Pediatrics animal diseases Health Toxicology and Mutagenesis hydrogen sulfide asthma school screening Disease ammonia hygiene hypothesis Cohort Studies chronic wheeze Sex factors immune system diseases Risk Factors Nonfarm payrolls Child asthma undertreatment Agriculture Articles Respiratory Function Tests Treatment Outcome Child Preschool Cohort Children's Health Female Cohort study medicine.medical_specialty Adolescent odor agricultural occupational exposures animal feeding operations farming Sex Factors Hygiene hypothesis children Environmental health medicine Humans cough with exercise Asthma business.industry Public Health Environmental and Occupational Health Infant Newborn Infant asthma asthma diagnosis and treatment Models Theoretical medicine.disease Iowa respiratory tract diseases body regions Epidemiologic Studies genetic selection asthma underdiagnosis Genetic selection rural business asthma health care policy |
| Zdroj: | Environmental Health Perspectives |
| ISSN: | 1552-9924 0091-6765 |
| Popis: | Epidemiologic studies of farm children are of international interest because farm children are less often atopic, have less allergic disease, and often have less asthma than do nonfarm children--findings consistent with the hygiene hypothesis. We studied a cohort of rural Iowa children to determine the association between farm and other environmental risk factors with four asthma outcomes: doctor-diagnosed asthma, doctor-diagnosed asthma/medication for wheeze, current wheeze, and cough with exercise. Doctor-diagnosed asthma prevalence was 12%, but at least one of these four health outcomes was found in more than a third of the cohort. Multivariable models of the four health outcomes found independent associations between male sex (three asthma outcomes), age (three asthma outcomes), a personal history of allergies (four asthma outcomes), family history of allergic disease (two asthma outcomes), premature birth (one asthma outcome), early respiratory infection (three asthma outcomes), high-risk birth (two asthma outcomes), and farm exposure to raising swine and adding antibiotics to feed (two asthma outcomes). The high prevalence of rural childhood asthma and asthma symptoms underscores the need for asthma screening programs and improved asthma diagnosis and treatment. The high prevalence of asthma health outcomes among farm children living on farms that raise swine (44.1%, p = 0.01) and raise swine and add antibiotics to feed (55.8%, p = 0.013), despite lower rates of atopy and personal histories of allergy, suggests the need for awareness and prevention measures and more population-based studies to further assess environmental and genetic determinants of asthma among farm children. |
| Databáze: | OpenAIRE |
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