Diffusion anisotropy measurements in ischaemic stroke of the human brain

Autor:	P. A. Armitage, M. E. Bastin, I. Marshall, J. M. Wardlaw, J. Cannon
Rok vydání:	1998
Předmět:	Adult Radiological and Ultrasound Technology Phantoms Imaging Biophysics Middle Aged Magnetic Resonance Imaging Brain Ischemia Diffusion Cerebrovascular Disorders Acute Disease Anisotropy Humans Radiology Nuclear Medicine and imaging Aged
Zdroj:	Magma (New York, N.Y.). 6(1)
ISSN:	0968-5243
Popis:	Magnetic resonance diffusion imaging was performed on 12 patients presenting with symptoms of acute ischaemic stroke (1-6 days post-ictus). Apparent diffusion coefficient (ADC) and diffusion anisotropy measurements were obtained from ischaemic and contralateral normal regions. ADC measurements were decreased by around 40% in ischaemic regions, indicated by an average stroke to normal ratio of 0.56 +/- 0.04 (p0.0001). The measured anisotropy was shown to be significantly increased in ischaemic regions, using both standard deviation and volume ratio anisotropy indices, which gave stroke to normal ratios of 1.78 +/- 0.27 (p = 0.003) and 0.87 +/- 0.05 (p = 0.005) respectively. The effects of gradient interactions, image registration, noise contamination and rotational variance and their implications for the results obtained in this study are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e921ed3d3d7db8028471ed21fa9c59b5 https://pubmed.ncbi.nlm.nih.gov/9794287 Zobrazit plný text záznamu Full text from SpringerLink